4. For each of the following molecules, circle the most acidic (unstable) hydrogen atom and estimate its pka value. You may need to draw in the most acidic hydrogen if it is implied. HO HO CH3 O NH₂ OH SH pka : pka : pka : HO H₂O H₂N O= 0= OH OH H pka: pka : pka :

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### Question 4

For each of the following molecules, circle the most acidic (unstable) hydrogen atom and estimate its pKa value. You may need to draw in the most acidic hydrogen if it is implied.

1. **Molecule A**: Phenol derivative with a methyl group attached to the benzene ring.
   - **Diagram**: Benzene ring with an OH (hydroxyl) group and a CH₃ (methyl) group.
   - **pKa**: _______

2. **Molecule B**: Amide with isopropyl substituent.
   - **Diagram**: Amide group with a NH₂ group next to a carbonyl.
   - **pKa**: _______

3. **Molecule C**: Thiol with a carboxyl group.
   - **Diagram**: Contains an OH group, followed by SH (thiol), linked to a carbonyl.
   - **pKa**: _______

4. **Molecule D**: Sulfonic acid derivative.
   - **Diagram**: Benzene ring with an SO₃H (sulfonic acid) group.
   - **pKa**: _______

5. **Molecule E**: Carboxylic acid with a benzene ring.
   - **Diagram**: Benzene ring attached to a COOH (carboxylic acid) group. It's shown in presence of H₂O.
   - **pKa**: _______

6. **Molecule F**: Protonated amide.
   - **Diagram**: NH₃⁺ group next to a carbonyl, indicating a protonated form.
   - **pKa**: _______

7. **Molecule G**: Pyridine derivative.
   - **Diagram**: Contains a nitrogen atom within a heterocyclic aromatic ring and an NH group.
   - **pKa**: _______

8. **Molecule H**: Alkyne with an amine group.
   - **Diagram**: An alkyne with an NH₂ (amine) group attached.
   - **pKa**: _______

--- 

Each molecule's structure is described to help visualize the acidic hydrogen atoms you should be evaluating for pKa estimation.
Transcribed Image Text:Sure! Here’s a transcription suitable for an educational website: --- ### Question 4 For each of the following molecules, circle the most acidic (unstable) hydrogen atom and estimate its pKa value. You may need to draw in the most acidic hydrogen if it is implied. 1. **Molecule A**: Phenol derivative with a methyl group attached to the benzene ring. - **Diagram**: Benzene ring with an OH (hydroxyl) group and a CH₃ (methyl) group. - **pKa**: _______ 2. **Molecule B**: Amide with isopropyl substituent. - **Diagram**: Amide group with a NH₂ group next to a carbonyl. - **pKa**: _______ 3. **Molecule C**: Thiol with a carboxyl group. - **Diagram**: Contains an OH group, followed by SH (thiol), linked to a carbonyl. - **pKa**: _______ 4. **Molecule D**: Sulfonic acid derivative. - **Diagram**: Benzene ring with an SO₃H (sulfonic acid) group. - **pKa**: _______ 5. **Molecule E**: Carboxylic acid with a benzene ring. - **Diagram**: Benzene ring attached to a COOH (carboxylic acid) group. It's shown in presence of H₂O. - **pKa**: _______ 6. **Molecule F**: Protonated amide. - **Diagram**: NH₃⁺ group next to a carbonyl, indicating a protonated form. - **pKa**: _______ 7. **Molecule G**: Pyridine derivative. - **Diagram**: Contains a nitrogen atom within a heterocyclic aromatic ring and an NH group. - **pKa**: _______ 8. **Molecule H**: Alkyne with an amine group. - **Diagram**: An alkyne with an NH₂ (amine) group attached. - **pKa**: _______ --- Each molecule's structure is described to help visualize the acidic hydrogen atoms you should be evaluating for pKa estimation.
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