4. Enzyme regulation. Aspartate transcarbamoylase (ATCase) is the first enzyme in the metabolic pathway for pyrimidine biosynthesis. Explain how allostery regulates ATCase through conformational switches between T and R states. Describe the subunit composition of ATCase. What stabilizes each conformational state? [200 words or less.]
4. Enzyme regulation. Aspartate transcarbamoylase (ATCase) is the first enzyme in the metabolic pathway for pyrimidine biosynthesis. Explain how allostery regulates ATCase through conformational switches between T and R states. Describe the subunit composition of ATCase. What stabilizes each conformational state? [200 words or less.]
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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![4. Enzyme regulation. Aspartate transcarbamoylase (ATCase) is the first enzyme in the metabolic pathway
for pyrimidine biosynthesis. Explain how allostery regulates ATCase through conformational switches
between T and R states. Describe the subunit composition of ATCase. What stabilizes each conformational
state? [200 words or less.]](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F4403c3bf-9015-41b2-add3-f1d37d880ea3%2F77811ee1-f6df-48cb-b141-dfdcf9a53c44%2Fpzz0lpc_processed.jpeg&w=3840&q=75)
Transcribed Image Text:4. Enzyme regulation. Aspartate transcarbamoylase (ATCase) is the first enzyme in the metabolic pathway
for pyrimidine biosynthesis. Explain how allostery regulates ATCase through conformational switches
between T and R states. Describe the subunit composition of ATCase. What stabilizes each conformational
state? [200 words or less.]
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