Required information People suffering from chronic granulomatous disease (CGD) have a genetic disorder that prevents their phagocytes from producing hydrogen peroxide and certain other reactive oxygen species (ROS). ROS are produced in the phagolysosome of phagocytes cells in response to an increase in O2 consumption by that cell. ROS are toxic and play a role in the cell's antimicrobial defense, protecting that cell from invading bacteria in a manner not completely understood. People with CGD lack this protective ROS mechanism and suffer from recurrent bacterial infections, including pneumonia, skin infections, and abscesses. Certain bacteria have developed the ability to survive ROS, specifically by producing enzymes such as superoxide dismutase and catalase, which convert toxic ROS into 02 and water. Consider the figure below. Which step/component of phagocytosis is/are affected by the genetic defect causing CGD? Lysosomes Phagosome Phagolysosome Digestive enzymes
Required information People suffering from chronic granulomatous disease (CGD) have a genetic disorder that prevents their phagocytes from producing hydrogen peroxide and certain other reactive oxygen species (ROS). ROS are produced in the phagolysosome of phagocytes cells in response to an increase in O2 consumption by that cell. ROS are toxic and play a role in the cell's antimicrobial defense, protecting that cell from invading bacteria in a manner not completely understood. People with CGD lack this protective ROS mechanism and suffer from recurrent bacterial infections, including pneumonia, skin infections, and abscesses. Certain bacteria have developed the ability to survive ROS, specifically by producing enzymes such as superoxide dismutase and catalase, which convert toxic ROS into 02 and water. Consider the figure below. Which step/component of phagocytosis is/are affected by the genetic defect causing CGD? Lysosomes Phagosome Phagolysosome Digestive enzymes
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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People suffering from chronic granulomatous disease (CGD) have a genetic disorder that prevents their phagocytes from
producing hydrogen peroxide and certain other reactive oxygen species (ROS). ROS are produced in the phagolysosome
of phagocytes cells in response to an increase in O2 consumption by that cell. ROS are toxic and play a role in the cell's
antimicrobial defense, protecting that cell from invading bacteria in a manner not completely understood. People with
CGD lack this protective ROS mechanism and suffer from recurrent bacterial infections, including pneumonia, skin
infections, and abscesses. Certain bacteria have developed the ability to survive ROS, specifically by producing enzymes
such as superoxide dismutase and catalase, which convert toxic ROS into 02 and water.
Consider the figure below. Which step/component of phagocytosis is/are affected by the genetic defect causing CGD?
Lysosomes
Phagosome
Phogolysosome
Digestive
enzymes
Transcribed Image Text:Required information
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