4.- Determine the structural relationship between the compounds in each of the pairs that follow. They may be unrelated, identical (the same compound), constitutional isomers, diastereoisomers, enantiomers? - Identify the optically active (chiral) compounds and any meso compounds. - Assign a configuration (R or S) to all stereocenters. - Name all compounds so that the name reflects the structure unambiguously. a) b) c) CHO H- -NH₂ H- HO- -H CH₂OH H CH3 IQ H CH3 CI Ph H CH₂OH -OH HNH2 CHO H3C H I I Ph & I J. CI CH3

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**Exercise: Structural Relationships of Compounds**

**Instructions:**

For each of the following compound pairs, determine their structural relationship. They may be unrelated, identical (same compound), constitutional isomers, diastereoisomers, or enantiomers.

- Identify the optically active (chiral) compounds and any meso compounds.
- Assign a configuration (R or S) to all stereocenters.
- Name all compounds to clearly reflect their structure.

---

**Compound Pairs:**

**a)**

- **Compound 1:** Features an aldehyde group (CHO), hydroxyl groups (CH2OH), and an amino group (NH2) attached to a carbon chain.
- **Compound 2:** Similar structure to compound 1 but mirrored.

**b)**

- **Compound 1:** Cyclohexane ring with a hydrogen (H) and methyl group (CH3) in specific positions.
- **Compound 2:** Similar to compound 1 but with mirrored positioning of groups.

**c)**

- **Compound 1:** Cyclohexyl structure with phenyl (Ph), chlorine (Cl), hydrogen (H), and a methyl group (CH3).
- **Compound 2:** Configuration mirrored from compound 1.

**d)**

- **Compound 1:** Cyclopropane with carbonyl (C=O) and chlorine (Cl).
- **Compound 2:** Potentially different spatial arrangement compared to compound 1.

**e)**

- **Compound 1:** A six-membered ring with a hydroxyl group (OH), carbonyl, and methyl group (CH3).
- **Compound 2:** A five-membered ester with two methoxy groups (O-CH3).

**f)**

- **Compound 1:** Open chain form of a sugar with hydroxyl (OH) and methyl (CH3) groups.
- **Compound 2:** Closed ring sugar structure (pyranose form) with similar substituents as compound 1.

---

**Notes for Analysis:**

- Consider mirrored configurations for enantiomers.
- Note identical configurations for meso compounds.
- Use CIP (Cahn-Ingold-Prelog) rules for assigning R/S configurations.
- Ensure names reflect stereochemistry accurately.
Transcribed Image Text:**Exercise: Structural Relationships of Compounds** **Instructions:** For each of the following compound pairs, determine their structural relationship. They may be unrelated, identical (same compound), constitutional isomers, diastereoisomers, or enantiomers. - Identify the optically active (chiral) compounds and any meso compounds. - Assign a configuration (R or S) to all stereocenters. - Name all compounds to clearly reflect their structure. --- **Compound Pairs:** **a)** - **Compound 1:** Features an aldehyde group (CHO), hydroxyl groups (CH2OH), and an amino group (NH2) attached to a carbon chain. - **Compound 2:** Similar structure to compound 1 but mirrored. **b)** - **Compound 1:** Cyclohexane ring with a hydrogen (H) and methyl group (CH3) in specific positions. - **Compound 2:** Similar to compound 1 but with mirrored positioning of groups. **c)** - **Compound 1:** Cyclohexyl structure with phenyl (Ph), chlorine (Cl), hydrogen (H), and a methyl group (CH3). - **Compound 2:** Configuration mirrored from compound 1. **d)** - **Compound 1:** Cyclopropane with carbonyl (C=O) and chlorine (Cl). - **Compound 2:** Potentially different spatial arrangement compared to compound 1. **e)** - **Compound 1:** A six-membered ring with a hydroxyl group (OH), carbonyl, and methyl group (CH3). - **Compound 2:** A five-membered ester with two methoxy groups (O-CH3). **f)** - **Compound 1:** Open chain form of a sugar with hydroxyl (OH) and methyl (CH3) groups. - **Compound 2:** Closed ring sugar structure (pyranose form) with similar substituents as compound 1. --- **Notes for Analysis:** - Consider mirrored configurations for enantiomers. - Note identical configurations for meso compounds. - Use CIP (Cahn-Ingold-Prelog) rules for assigning R/S configurations. - Ensure names reflect stereochemistry accurately.
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