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4. A tRNA has the anticodon sequence 3'-CAG-5'. What amino acid does it carry? Illustrate how the anticodon of the tRNA interacts with its cognate codon on mRNA (you do not need to draw out the bases and their exact hydrogen bonding patterns; instead, you can just use the single letter abbreviations for the bases). Where is the anticodon located in the tRNA molecule? Where is the amino acid attached to the tRNA? Your illustration can include the overall general structure of a tRNA to address these questions.

4. A tRNA has the anticodon sequence 3'-CAG-5'. What amino acid does it carry? Illustrate how the anticodon of the tRNA interacts with its cognate codon on mRNA (you do not need to draw out the bases and their exact hydrogen bonding patterns; instead, you can just use the single letter abbreviations for the bases). Where is the anticodon located in the tRNA molecule? Where is the amino acid attached to the tRNA? Your illustration can include the overall general structure of a tRNA to address these questions.

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Question 4
**Transcription of Educational Content:** 1. **Identify the start codon, and determine the complete amino acid sequence that would be translated from this mRNA.** 2. **What does it mean when we say that the genetic code is (a) degenerate and (b) nonoverlapping?** 3. **How many different sequences of mRNA could encode a peptide with the sequence proline-glycine-methionine-serine? Be sure to show your work.** 4. **A tRNA has the anticodon sequence 3'-CAG-5'. What amino acid does it carry? Illustrate how the anticodon of the tRNA interacts with its cognate codon on mRNA (you do not need to draw out the bases and their exact hydrogen bonding patterns; instead, you can just use the single letter abbreviations for the bases). Where is the anticodon located in the tRNA molecule? Where is the amino acid attached to the tRNA? Your illustration can include the overall general structure of a tRNA to address these questions.** 5. **What is the role of aminoacyl-tRNA synthetase? The ability of aminoacyl-tRNA synthetases to recognize tRNAs has sometimes been called the "second genetic code." Why has the function of this enzyme been described this way?** 6. **For each of the following initiation factors (refer to the powerpoint slides), how would eukaryotic initiation of translation be affected if it were missing?** - **eIF2** - **eIF4** - **eIF5** 7. **Explain the functional roles of the A, P and E sites of a ribosome during translation.** 8. **Describe the mechanism of action for the following antibiotics on translation** a) **Chloramphenicol** b) **Erythromycin** c) **Puromycin** d) **Tetracycline** e) **Streptomycin**
Transcribed Image Text:**Transcription of Educational Content:** 1. **Identify the start codon, and determine the complete amino acid sequence that would be translated from this mRNA.** 2. **What does it mean when we say that the genetic code is (a) degenerate and (b) nonoverlapping?** 3. **How many different sequences of mRNA could encode a peptide with the sequence proline-glycine-methionine-serine? Be sure to show your work.** 4. **A tRNA has the anticodon sequence 3'-CAG-5'. What amino acid does it carry? Illustrate how the anticodon of the tRNA interacts with its cognate codon on mRNA (you do not need to draw out the bases and their exact hydrogen bonding patterns; instead, you can just use the single letter abbreviations for the bases). Where is the anticodon located in the tRNA molecule? Where is the amino acid attached to the tRNA? Your illustration can include the overall general structure of a tRNA to address these questions.** 5. **What is the role of aminoacyl-tRNA synthetase? The ability of aminoacyl-tRNA synthetases to recognize tRNAs has sometimes been called the "second genetic code." Why has the function of this enzyme been described this way?** 6. **For each of the following initiation factors (refer to the powerpoint slides), how would eukaryotic initiation of translation be affected if it were missing?** - **eIF2** - **eIF4** - **eIF5** 7. **Explain the functional roles of the A, P and E sites of a ribosome during translation.** 8. **Describe the mechanism of action for the following antibiotics on translation** a) **Chloramphenicol** b) **Erythromycin** c) **Puromycin** d) **Tetracycline** e) **Streptomycin**
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