4) An undergraduate researcher, James, was given the task of removing a t-butyl ether from the tyrosine derivative A to release the free phenol. James looked up a standard t-butyl ether removal procedure and ran the reaction. Instead of getting the desired product, B, he got a high yield of C. Show a reaction mechanism that explains why James did not get the desired product. Make sure your mechanism explains why James only got the ortho product. A HO. NHAC NHAC OBn OBn HO NHAC F3C OH OBn DCM, r.t. B 0% yield C 99% yield

Organic Chemistry
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ISBN:9781305080485
Author:John E. McMurry
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Chapter19: Aldehydes And Ketones: Nucleophilic Addition Reactions
Section19.SE: Something Extra
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4) An undergraduate researcher, James, was given the task of removing a t-butyl ether from the
tyrosine derivative A to release the free phenol. James looked up a standard t-butyl ether removal
procedure and ran the reaction. Instead of getting the desired product, B, he got a high yield of C.
Show a reaction mechanism that explains why James did not get the desired product. Make sure
your mechanism explains why James only got the ortho product.
A
HO.
NHAC
NHAC
OBn
OBn
HO
NHAC
F3C OH
OBn
DCM, r.t.
B 0% yield
C 99% yield
Transcribed Image Text:4) An undergraduate researcher, James, was given the task of removing a t-butyl ether from the tyrosine derivative A to release the free phenol. James looked up a standard t-butyl ether removal procedure and ran the reaction. Instead of getting the desired product, B, he got a high yield of C. Show a reaction mechanism that explains why James did not get the desired product. Make sure your mechanism explains why James only got the ortho product. A HO. NHAC NHAC OBn OBn HO NHAC F3C OH OBn DCM, r.t. B 0% yield C 99% yield
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