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35. What is the approximate pl for the peptide MEKVDRP. Because this is a peptide, assume the pka for the amino terminus is 9.0 and the pka for the carboxyl terminus is 3.5. a. 4.5 b. 6.5 c. 7.5 d. 9.5 pka's are 3.5 (C-terminus), 4.0 (Glutamic Acid), 3.9 (Aspartic Acid), 9.0 (N-terminus), 10.5 (Lysine), 12.5 (Arginine)

35. What is the approximate pl for the peptide MEKVDRP. Because this is a peptide, assume the pka for the amino terminus is 9.0 and the pka for the carboxyl terminus is 3.5. a. 4.5 b. 6.5 c. 7.5 d. 9.5 pka's are 3.5 (C-terminus), 4.0 (Glutamic Acid), 3.9 (Aspartic Acid), 9.0 (N-terminus), 10.5 (Lysine), 12.5 (Arginine)

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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35. What is the approximate pl for the peptide MEKVDRP. Because this is a peptide, assume the pka for the amino terminus is 9.0 and the pka for the carboxyl terminus is 3.5. a. 4.5 b. 6.5 c. 7.5 d. 9.5 pka's are 3.5 (C-terminus), 4.0 (Glutamic Acid), 3.9 (Aspartic Acid), 9.0 (N-terminus), 10.5 (Lysine), 12.5 (Arginine) There are 3 bases and 3 acids. Therefore the, pl will be the average of the internal acid and base pka's. Roughly, 3.5 and 3.9 cancel with 10.5 and 12.5. The remaining. are 4.0 (Glutamic Acid) and 9.0 (N- terminus). Average is about 6.5
Transcribed Image Text:35. What is the approximate pl for the peptide MEKVDRP. Because this is a peptide, assume the pka for the amino terminus is 9.0 and the pka for the carboxyl terminus is 3.5. a. 4.5 b. 6.5 c. 7.5 d. 9.5 pka's are 3.5 (C-terminus), 4.0 (Glutamic Acid), 3.9 (Aspartic Acid), 9.0 (N-terminus), 10.5 (Lysine), 12.5 (Arginine) There are 3 bases and 3 acids. Therefore the, pl will be the average of the internal acid and base pka's. Roughly, 3.5 and 3.9 cancel with 10.5 and 12.5. The remaining. are 4.0 (Glutamic Acid) and 9.0 (N- terminus). Average is about 6.5
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