34. A 24-year-old woman has nystagmus and diplopia. She has been treated for the past 2 months with steadily increasing doses of phenytoin for simple partial seizures. Her serum concentrations of phenytoin have increased disproportionately to the increases in dose. Which of the following features of high-dose phenytoin best explains the disproportionate increase in her serum phenytoin concentration? OA) Decreases the hepatic blood flow glucuronic acid B) Decreases the hepatic concentration C) Exceeds the capacity of hepatic metabolism of phenytoin OD) Exceeds the capacity of urinary excretion E) Increases the binding of phenytoin to plasma proteins
34. A 24-year-old woman has nystagmus and diplopia. She has been treated for the past 2 months with steadily increasing doses of phenytoin for simple partial seizures. Her serum concentrations of phenytoin have increased disproportionately to the increases in dose. Which of the following features of high-dose phenytoin best explains the disproportionate increase in her serum phenytoin concentration? OA) Decreases the hepatic blood flow glucuronic acid B) Decreases the hepatic concentration C) Exceeds the capacity of hepatic metabolism of phenytoin OD) Exceeds the capacity of urinary excretion E) Increases the binding of phenytoin to plasma proteins
Chapter9: Parenteral Medication Labels And Dosage Calculation
Section: Chapter Questions
Problem 7.7P
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