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3. Many medications are absorbed into the blood through the cells lining the stomach and small intestine. The rate of absorption (passage through a cell membrane into the blood stream) for a molecule depends on the structure and properties of the molecule. Remember, the cell membrane is a bilayer composed polar head groups (circles on top and bottom) on the exterior and a large non-polar central region. (see example structure to the right). Bilayer e a) Which substance would be more easily absorbed into the blood stream; a polar, ionic, or non- polar substance? Choose one and justify your reasoning using chemical and molecular details. b) Furosemide (structure shown on the right) is a diuretic used to treat fluid retention in patients with congestive heart failure or liver disease, among others. It a weak acid with a pKa of 3.9. It is absorbed into the blood through the cells lining the stomach (pH 1.5) and the small intestine (pH 6.0). H2N, CI i) circle the most acidic proton in the structure below. ii) Is more furosemide absorbed into the bloodstream from the stomach or the small intestine? Clearly justify your answer using chemical and molecular details. ZI

3. Many medications are absorbed into the blood through the cells lining the stomach and small intestine. The rate of absorption (passage through a cell membrane into the blood stream) for a molecule depends on the structure and properties of the molecule. Remember, the cell membrane is a bilayer composed polar head groups (circles on top and bottom) on the exterior and a large non-polar central region. (see example structure to the right). Bilayer e a) Which substance would be more easily absorbed into the blood stream; a polar, ionic, or non- polar substance? Choose one and justify your reasoning using chemical and molecular details. b) Furosemide (structure shown on the right) is a diuretic used to treat fluid retention in patients with congestive heart failure or liver disease, among others. It a weak acid with a pKa of 3.9. It is absorbed into the blood through the cells lining the stomach (pH 1.5) and the small intestine (pH 6.0). H2N, CI i) circle the most acidic proton in the structure below. ii) Is more furosemide absorbed into the bloodstream from the stomach or the small intestine? Clearly justify your answer using chemical and molecular details. ZI

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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3. Many medications are absorbed into the blood through the cells lining the stomach and small intestine. The rate of absorption (passage through a cell membrane into the blood stream) for a molecule depends on the structure and properties of the molecule. Remember, the cell membrane is a bilayer composed polar head groups (circles on top and bottom) on the exterior and a large non-polar central region. (see example structure to the right). Bilayer e a) Which substance would be more easily absorbed into the blood stream; a polar, ionic, or non- polar substance? Choose one and justify your reasoning using chemical and molecular details. b) Furosemide (structure shown on the right) is a diuretic used to treat fluid retention in patients with congestive heart failure or liver disease, among others. It a weak acid with a pKa of 3.9. It is absorbed into the blood through the cells lining the stomach (pH 1.5) and the small intestine (pH 6.0). H2N, `OH CI N' i) circle the most acidic proton in the structure below. ii) Is more furosemide absorbed into the bloodstream from the stomach or the small intestine? Clearly justify your answer using chemical and molecular details. ZI
Transcribed Image Text:3. Many medications are absorbed into the blood through the cells lining the stomach and small intestine. The rate of absorption (passage through a cell membrane into the blood stream) for a molecule depends on the structure and properties of the molecule. Remember, the cell membrane is a bilayer composed polar head groups (circles on top and bottom) on the exterior and a large non-polar central region. (see example structure to the right). Bilayer e a) Which substance would be more easily absorbed into the blood stream; a polar, ionic, or non- polar substance? Choose one and justify your reasoning using chemical and molecular details. b) Furosemide (structure shown on the right) is a diuretic used to treat fluid retention in patients with congestive heart failure or liver disease, among others. It a weak acid with a pKa of 3.9. It is absorbed into the blood through the cells lining the stomach (pH 1.5) and the small intestine (pH 6.0). H2N, `OH CI N' i) circle the most acidic proton in the structure below. ii) Is more furosemide absorbed into the bloodstream from the stomach or the small intestine? Clearly justify your answer using chemical and molecular details. ZI
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