3. Huntington disease is a late-onset disease caused by a single, dominant mutation. The following pedigree is for a family with a history of Huntington disease. Those individuals who are already suffering from the disease are shaded black. However, some additional individuals in generations II and Ill also have the Huntington allele and will develop Huntington disease but have not yet shown symptoms. Assume that individuals marrying into the family have no history of Huntington disease (that is, they are homozygous recessive for the gene). Also assume that the diseased male in generation I is heterozygous for the gene and his wife is homozygous recessive. I II III abcdefghijklm

Human Anatomy & Physiology (11th Edition)
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What is the probability that III-j has Huntington's?

3. Huntington disease is a late-onset disease caused by a single, dominant mutation. The following
pedigree is for a family with a history of Huntington disease. Those individuals who are already
suffering from the disease are shaded black. However, some additional individuals in generations II and
Ill also have the Huntington allele and will develop Huntington disease but have not yet shown
symptoms. Assume that individuals marrying into the family have no history of Huntington disease (that
is, they are homozygous recessive for the gene). Also assume that the diseased male in generation I is
heterozygous for the gene and his wife is homozygous recessive.
I
II
III
abcdefghijklm
Transcribed Image Text:3. Huntington disease is a late-onset disease caused by a single, dominant mutation. The following pedigree is for a family with a history of Huntington disease. Those individuals who are already suffering from the disease are shaded black. However, some additional individuals in generations II and Ill also have the Huntington allele and will develop Huntington disease but have not yet shown symptoms. Assume that individuals marrying into the family have no history of Huntington disease (that is, they are homozygous recessive for the gene). Also assume that the diseased male in generation I is heterozygous for the gene and his wife is homozygous recessive. I II III abcdefghijklm
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