Huntington's disease ia an autosomal dominant disorder. A heterozygous female mates with a nondiseased male. What is the chance a child will have the disease? 1) 0% 2) 25% 3) 50% 4) 75% 5) 100%

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**Genetics and Heredity: Understanding Autosomal Dominant Disorders**

**Question:**

Huntington's disease is an autosomal dominant disorder. A heterozygous female mates with a nondiseased male. What is the chance a child will have the disease?

1) 0%

2) 25%

3) 50%

4) 75%

5) 100%

---

**Explanation:**

Huntington's disease is an example of an autosomal dominant disorder. This means that only one copy of the mutated gene is required for an individual to exhibit symptoms of the disease. In genetic terms, dominant alleles mask the expression of recessive alleles in heterozygous individuals.

**Genotype Symbols:**
- Let \( H \) represent the dominant allele for Huntington's disease.
- Let \( h \) represent the normal recessive allele.

**Parent Genotypes:**
- Heterozygous female: \( Hh \)
- Nondiseased male: \( hh \)

**Punnett Square Analysis:**
To determine the probability of their offspring inheriting Huntington's disease, we use a Punnett square to evaluate the combinations of alleles.

|         | \( h \) (Male)  | \( h \) (Male)  |
|---------|:---------------:|:---------------:|
| \( H \) (Female) |   **Hh**       |    **Hh**       |
| \( h \) (Female) |   **hh**       |    **hh**       |

**Results:**
From the Punnett square, we see that there are four possible combinations for the offspring:
- 2 out of 4 (50%) are **Hh** (showing the disease)
- 2 out of 4 (50%) are **hh** (normal)

**Conclusion:**
The chance that a child will inherit Huntington's disease from these parents is **50%**.

**Answer:** 3) 50%

---

Understanding genetic principles through examples like Huntington's disease can provide crucial insights into heredity and medical genetics. For more details and explorations, check our topics on Genetic Disorders and Hereditary Patterns.

---
Transcribed Image Text:--- **Genetics and Heredity: Understanding Autosomal Dominant Disorders** **Question:** Huntington's disease is an autosomal dominant disorder. A heterozygous female mates with a nondiseased male. What is the chance a child will have the disease? 1) 0% 2) 25% 3) 50% 4) 75% 5) 100% --- **Explanation:** Huntington's disease is an example of an autosomal dominant disorder. This means that only one copy of the mutated gene is required for an individual to exhibit symptoms of the disease. In genetic terms, dominant alleles mask the expression of recessive alleles in heterozygous individuals. **Genotype Symbols:** - Let \( H \) represent the dominant allele for Huntington's disease. - Let \( h \) represent the normal recessive allele. **Parent Genotypes:** - Heterozygous female: \( Hh \) - Nondiseased male: \( hh \) **Punnett Square Analysis:** To determine the probability of their offspring inheriting Huntington's disease, we use a Punnett square to evaluate the combinations of alleles. | | \( h \) (Male) | \( h \) (Male) | |---------|:---------------:|:---------------:| | \( H \) (Female) | **Hh** | **Hh** | | \( h \) (Female) | **hh** | **hh** | **Results:** From the Punnett square, we see that there are four possible combinations for the offspring: - 2 out of 4 (50%) are **Hh** (showing the disease) - 2 out of 4 (50%) are **hh** (normal) **Conclusion:** The chance that a child will inherit Huntington's disease from these parents is **50%**. **Answer:** 3) 50% --- Understanding genetic principles through examples like Huntington's disease can provide crucial insights into heredity and medical genetics. For more details and explorations, check our topics on Genetic Disorders and Hereditary Patterns. ---
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