3. Following the bolus iv injection of 58 mg/kg of radiolabeled methacrylonitrile (MAN, an industrial solvent) in rats, measurements were made of the amount of MAN excreted in urine and the amount exhaled as MAN, acetone, or CO2. The results are summarized below as the cumulative percent of administered dose excreted by each route. MAN is not significantly excreted by any other routes than those measured. Time after Cumulative %Dose Excreted via Injection Urine Exhaled Exhaled Exhaled (hr) MAN CO2 Acetone 0 0.0 0.0 0.0 0.0 1 0.7 17.2 0.9 0.3 2 2.9 27.4 2.7 1.1 4 6.8 33.7 7.2 5.4 8 11.8 35.3 12.7 11.1 12 13.6 35.3 16.5 14.7 24 15.8 35.5 27.2 17.4 Using this data, estimate the "whole body" half-life of MAN in rats.
3. Following the bolus iv injection of 58 mg/kg of radiolabeled methacrylonitrile (MAN, an industrial solvent) in rats, measurements were made of the amount of MAN excreted in urine and the amount exhaled as MAN, acetone, or CO2. The results are summarized below as the cumulative percent of administered dose excreted by each route. MAN is not significantly excreted by any other routes than those measured. Time after Cumulative %Dose Excreted via Injection Urine Exhaled Exhaled Exhaled (hr) MAN CO2 Acetone 0 0.0 0.0 0.0 0.0 1 0.7 17.2 0.9 0.3 2 2.9 27.4 2.7 1.1 4 6.8 33.7 7.2 5.4 8 11.8 35.3 12.7 11.1 12 13.6 35.3 16.5 14.7 24 15.8 35.5 27.2 17.4 Using this data, estimate the "whole body" half-life of MAN in rats.
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Transcribed Image Text:3. Following the bolus iv injection of 58 mg/kg of radiolabeled methacrylonitrile (MAN, an
industrial solvent) in rats, measurements were made of the amount of MAN excreted in urine
and the amount exhaled as MAN, acetone, or CO2. The results are summarized below as the
cumulative percent of administered dose excreted by each route. MAN is not significantly
excreted by any other routes than those measured.
Time after
Cumulative %Dose Excreted via
Injection
Urine
Exhaled
Exhaled
Exhaled
(hr)
MAN
CO2
Acetone
0
0.0
0.0
0.0
0.0
1
0.7
17.2
0.9
0.3
2
2.9
27.4
2.7
1.1
4
6.8
33.7
7.2
5.4
8
11.8
35.3
12.7
11.1
12
13.6
35.3
16.5
14.7
24
15.8
35.5
27.2
17.4
Using this data, estimate the "whole body" half-life of MAN in rats.
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