3. Compound A has an Rf of 0.75 and compound B has an Rf of 0.35. Which compound will elute first from a silica gel column using the same solvent system as in TLC?

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**Question 3:**

Compound A has an Rf of 0.75 and compound B has an Rf of 0.35. Which compound will elute first from a silica gel column using the same solvent system as in TLC?

**Explanation:**
In Thin Layer Chromatography (TLC), the Rf (retention factor) value indicates how far a compound travels relative to the solvent front. A higher Rf means the compound is less polar and interacts less with the stationary phase (silica gel) and more with the mobile phase (solvent). 

In column chromatography, similar principles are applied. Therefore, compound A, with a higher Rf of 0.75, will elute first as it travels more quickly through the column in the same solvent system.
Transcribed Image Text:**Question 3:** Compound A has an Rf of 0.75 and compound B has an Rf of 0.35. Which compound will elute first from a silica gel column using the same solvent system as in TLC? **Explanation:** In Thin Layer Chromatography (TLC), the Rf (retention factor) value indicates how far a compound travels relative to the solvent front. A higher Rf means the compound is less polar and interacts less with the stationary phase (silica gel) and more with the mobile phase (solvent). In column chromatography, similar principles are applied. Therefore, compound A, with a higher Rf of 0.75, will elute first as it travels more quickly through the column in the same solvent system.
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