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3. Assume that 10 mg of a drug was dissolved in 100 ml to make an intravenous infusion. The same amount was injected intravenously. Plasma samples were withdrawn every 4 hours for a day. The following data were generated. Plasma drug concentration(ug/ml) Time(hr) 100 50 4 25 8 12.5 12 6.25 16 3.13 20 1.56 24 Required: A. Plot a graph on coordinate plane based on the above data B. Based on the graph, determine the order of the drug kinetics and give reason why the order is as such? C. Determine the types of order rate constant. Does it agree with your answer to 'B'? D. Label both t12 & elimination rate constant on a graph plotted for 'A', above. Do

3. Assume that 10 mg of a drug was dissolved in 100 ml to make an intravenous infusion. The same amount was injected intravenously. Plasma samples were withdrawn every 4 hours for a day. The following data were generated. Plasma drug concentration(ug/ml) Time(hr) 100 50 4 25 8 12.5 12 6.25 16 3.13 20 1.56 24 Required: A. Plot a graph on coordinate plane based on the above data B. Based on the graph, determine the order of the drug kinetics and give reason why the order is as such? C. Determine the types of order rate constant. Does it agree with your answer to 'B'? D. Label both t12 & elimination rate constant on a graph plotted for 'A', above. Do

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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3. Assume that 10 mg of a drug was dissolved in 100 ml to make an intravenous infusion. The same amount was injected intravenously. Plasma samples were withdrawn every 4 hours for a day. The following data were generated. Plasma drug concentration(ug/ml) Time(hr) 100 50 4 25 8 12.5 12 6.25 16 3.13 20 1.56 24 Required: A. Plot a graph on coordinate plane based on the above data B. Based on the graph, determine the order of the drug kinetics and give reason why the order is as such? C. Determine the types of order rate constant. Does it agree with your answer to 'B'? D. Label both t2 & elimination rate constant on a graph plotted for 'A', above. Do
Transcribed Image Text:3. Assume that 10 mg of a drug was dissolved in 100 ml to make an intravenous infusion. The same amount was injected intravenously. Plasma samples were withdrawn every 4 hours for a day. The following data were generated. Plasma drug concentration(ug/ml) Time(hr) 100 50 4 25 8 12.5 12 6.25 16 3.13 20 1.56 24 Required: A. Plot a graph on coordinate plane based on the above data B. Based on the graph, determine the order of the drug kinetics and give reason why the order is as such? C. Determine the types of order rate constant. Does it agree with your answer to 'B'? D. Label both t2 & elimination rate constant on a graph plotted for 'A', above. Do
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