3. Administration of a drug that inhibits Na+ reabsorption by the thick ascending limb of the loop of Henle results in which of the following?OA) Decreased ability to excrete maximally concentrated urineOB) Decreased K+ excretionC) Decreased Na+ reabsorption by the collecting ductOD) Increased fluid reabsorption by the proximal tubule.OE) Increased urea reabsorption by the collecting duct

Answered: 3. Administration of a drug that…

Phlebotomy Essentials

6th Edition

ISBN:9781451194524

Author:Ruth McCall, Cathee M. Tankersley MT(ASCP)

Publisher:Ruth McCall, Cathee M. Tankersley MT(ASCP)

Chapter1: Phlebotomy: Past And Present And The Healthcare Setting

Section: Chapter Questions

Problem 1SRQ

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Question

3. Administration of a drug that inhibits Na+ reabsorption by the thick ascending limb of the loop of Henle results in which of the following?
OA) Decreased ability to excrete maximally concentrated urine
OB) Decreased K+ excretion
C) Decreased Na+ reabsorption by the collecting duct
OD) Increased fluid reabsorption by the proximal tubule.
OE) Increased urea reabsorption by the collecting duct

Expert Solution

Step 1

Within the nephrons, the ascending of the loop of henle is divided into thick and thin portions. The thick portion of the ascending limb is largely permeable to water. Reabsorption of sodium, potassium and chloride ions occur at this site by active transport. This segment accounts for about 25 to 30% of total sodium reabsorption through the nephron. The mechanism of active transport in this segment is Sodium, Potassium, Chloride cotransporter NKCC2 and the sodium/hydrogen exchanger.

Variation in sodium uptake by the thick ascending limb of the loop of Henle influences a person's chronic level of blood pressure as well as the risk for Hypertension.