3. Above is a relative of S-adenosylmethionine (SAM) called S-adenosvlnethionineamine (while there isno common abbreviation for this molecule, here we can call it SAMN). Note that R'-S-R is a very goodleaving group. You do not need to know anything else about sulfur to answer this question. It isrecommended to work this problem after Problem 2, keeping in mind the three circled carbon atomsfrom Problem 2. To save excessive writing, you may abbreviate adenosine as "Ado" as shown in thepathway diagram below.a) SAMN can serve as more than a methylating agent. Do you think that its intrinsic chemicalactivity as a methylating agent is substantially more, șimilar to, or less than SAM?b) SAMN is used in biochemistry in the below pathway, which converts the stinky diamineputrescine into the "polyamine" spermine which is used biologically for offsetting thenegative charges in DNA. Draw spermine in its most common protonation state at pH 7.c) Draw the reaction of putrescine with SAMN (shown as with the adenosine abbreviated as"Ado" in the below diagram) to form spermidine using the arrow formalism.H2N.putrescine`NH2H2N.spermidinesynthase`Ado`AdoHN.`NH2spermidinesperminesynthaseH2N.`NH, spermined) Would the reaction to form spermidine tend to occur more rapidly at pH 5 or pH 9?e) A similar reaction can yield spermine. Draw this reaction.

The objective of this question is to show the presence of a good leaving group, R-S-R, explain…

3. Above is a relative of S-adenosylmethionine (SAM) called S-adenosvlmethionineamine (while there is no common abbreviation for this molecule, here we can call it SAMN). Note that R'-S-R is a very good leaving group. You do not need to know anything else about sulfur to answer this question. It is recommended to work this problem after Problem 2, keeping in mind the three circled carbon atoms from Problem 2. To save excessive writing, you may abbreviate adenosine as "Ado" as shown in the pathway diagram below. a) b) SAMN can serve as more than a methylating agent. Do you think that its intrinsic chemical activity as a methylating agent is substantially more, similar to, or less than SAM? SAMN is used in biochemistry in the below pathway, which converts the stinky diamine putrescine into the "polyamine" spermine which is used biologically for offsetting the negative charges in DNA. Draw spermine in its most common protonation state at pH 7. c) Draw the reaction of putrescine with SAMN (shown as with the adenosine abbreviated as "Ado" in the below diagram) to form spermidine using the arrow formalism. putrescine H₂N- H₂N spermidine synthase H₂N spermine synthase NH₂ H₂N. S-Ado NH₂ spermidine NH₂ spermine

3. Above is a relative of S-adenosylmethionine (SAM) called S-adenosvlmethionineamine (while there is no common abbreviation for this molecule, here we can call it SAMN). Note that R'-S-R is a very good leaving group. You do not need to know anything else about sulfur to answer this question. It is recommended to work this problem after Problem 2, keeping in mind the three circled carbon atoms from Problem 2. To save excessive writing, you may abbreviate adenosine as "Ado" as shown in the pathway diagram below. a) b) SAMN can serve as more than a methylating agent. Do you think that its intrinsic chemical activity as a methylating agent is substantially more, similar to, or less than SAM? SAMN is used in biochemistry in the below pathway, which converts the stinky diamine putrescine into the "polyamine" spermine which is used biologically for offsetting the negative charges in DNA. Draw spermine in its most common protonation state at pH 7. c) Draw the reaction of putrescine with SAMN (shown as with the adenosine abbreviated as "Ado" in the below diagram) to form spermidine using the arrow formalism. putrescine H₂N- H₂N spermidine synthase H₂N spermine synthase NH₂ H₂N. S-Ado NH₂ spermidine NH₂ spermine

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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