3. Above is a relative of S-adenosylmethionine (SAM) called S-adenosvlnethionineamine (while there isno common abbreviation for this molecule, here we can call it SAMN). Note that R'-S-R is a very goodleaving group. You do not need to know anything else about sulfur to answer this question. It isrecommended to work this problem after Problem 2, keeping in mind the three circled carbon atomsfrom Problem 2. To save excessive writing, you may abbreviate adenosine as "Ado" as shown in thepathway diagram below.a) SAMN can serve as more than a methylating agent. Do you think that its intrinsic chemicalactivity as a methylating agent is substantially more, șimilar to, or less than SAM?b) SAMN is used in biochemistry in the below pathway, which converts the stinky diamineputrescine into the "polyamine" spermine which is used biologically for offsetting thenegative charges in DNA. Draw spermine in its most common protonation state at pH 7.c) Draw the reaction of putrescine with SAMN (shown as with the adenosine abbreviated as"Ado" in the below diagram) to form spermidine using the arrow formalism.H2N.putrescine`NH2H2N.spermidinesynthase`Ado`AdoHN.`NH2spermidinesperminesynthaseH2N.`NH, spermined) Would the reaction to form spermidine tend to occur more rapidly at pH 5 or pH 9?e) A similar reaction can yield spermine. Draw this reaction.

The objective of this question is to show the presence of a good leaving group, R-S-R, explain…

3. Above is a relative of S-adenosylmethionine (SAM) called S-adenosvlmethionineamine (while there is no common abbreviation for this molecule, here we can call it SAMN). Note that R'-S-R is a very good leaving group. You do not need to know anything else about sulfur to answer this question. It is recommended to work this problem after Problem 2, keeping in mind the three circled carbon atoms from Problem 2. To save excessive writing, you may abbreviate adenosine as "Ado" as shown in the pathway diagram below. a) b) SAMN can serve as more than a methylating agent. Do you think that its intrinsic chemical activity as a methylating agent is substantially more, similar to, or less than SAM? SAMN is used in biochemistry in the below pathway, which converts the stinky diamine putrescine into the "polyamine" spermine which is used biologically for offsetting the negative charges in DNA. Draw spermine in its most common protonation state at pH 7. c) Draw the reaction of putrescine with SAMN (shown as with the adenosine abbreviated as "Ado" in the below diagram) to form spermidine using the arrow formalism. putrescine H₂N- H₂N spermidine synthase H₂N spermine synthase NH₂ H₂N. S-Ado NH₂ spermidine NH₂ spermine

3. Above is a relative of S-adenosylmethionine (SAM) called S-adenosvlmethionineamine (while there is no common abbreviation for this molecule, here we can call it SAMN). Note that R'-S-R is a very good leaving group. You do not need to know anything else about sulfur to answer this question. It is recommended to work this problem after Problem 2, keeping in mind the three circled carbon atoms from Problem 2. To save excessive writing, you may abbreviate adenosine as "Ado" as shown in the pathway diagram below. a) b) SAMN can serve as more than a methylating agent. Do you think that its intrinsic chemical activity as a methylating agent is substantially more, similar to, or less than SAM? SAMN is used in biochemistry in the below pathway, which converts the stinky diamine putrescine into the "polyamine" spermine which is used biologically for offsetting the negative charges in DNA. Draw spermine in its most common protonation state at pH 7. c) Draw the reaction of putrescine with SAMN (shown as with the adenosine abbreviated as "Ado" in the below diagram) to form spermidine using the arrow formalism. putrescine H₂N- H₂N spermidine synthase H₂N spermine synthase NH₂ H₂N. S-Ado NH₂ spermidine NH₂ spermine

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

See similar textbooks

Similar questions

Draw two cyclic constitutional isomers of trans-1,2-dimethylcyclopentane with the same size ring. • In cases where there is only one cyclic constitutional isomer, just draw one structure. • If there are more than two isomers, draw any two of the possible structures. • Your drawing must specify cis/trans stereochemistry unambiguously using wedged and dashed bonds. • Draw one structure per sketcher. Add additional sketchers using the drop-down menu in the bottom right corner. ? ChemDoodle it's
4. Draw all products for each of the following reactions or reaction sequences. For chiral molecules that are racemic, you needn't draw both enantiomers (just write if it exists an enantiomer). BE CAREFUL TO SHOW THE CORRECT ORIENTATION, AND THE CORRECT STEREOCHEMISTRY IN CASES WHERE STEREOCHEM IS FACTOR. Write also the name of the reaction that is occurring. OK Ph THE Br
6. Connection to Biology. In each of the pharmaceuticals shown below, circle the most basic site. a) NH₂ a) Amphetamine b) OH Vitamin A (2E,4E,6E,8E)-3,7-dimethyl-9- (2,6,6-trimethylcyclohex-1-en-1- yl)nona-2,4,6,8-tetraen-1-ol F b) ד ד F F NH₂ HO,.. Fluvoxamine 7. Connection to Biology. In each of the vitamins shown below, circle the most acid site/proton. Check out their chemical names - this makes is clear why we have 'common' names for them! Lap c) Vitamin D (1S,Z)-3-(2-((1R,7aR,E)-1- ((2R,5R,E)-5,6-dimethylhept-3-en-2- yl)-7a-methyloctahydro-4H-inden-4- ylidene)ethylidene)-4- methylenecyclohexan-1-ol c) ОН но Tramadol N. Но HO OH Vitamin C Ascorbic Acid or (R)-5-((S)-1,2- dihydroxyethyl)-3,4- dihydroxyfuran-2(5H) -one
3
Using dash–wedge notation to designate stereochemistry, draw (R)-pentane-1,2-diol.
Kinetic control At low temperatures, molecules have low amounts of kinetic energy and therefore predominantly react through the pathway that has the lowest energy of activation and therefore proceeds at a faster rate. The product obtained through this pathway is referred to as the kinetic product. ▼ Part B Give the structure of compound A, the major product when the reaction is conducted at low temperatures. Draw the molecule on the canvas by choosing buttons from the Tools (for bonds), Atoms, and Advanced Template toolbars. The single bond is active by default. ► View Available Hint(s) Love + H-Br -55 °C A NN [1] A ⒸH: 120 EXP. CONT Marvin JS by ChemAxon SOZ O IL H N CI Br 1 P F
Need help, please.
Arrange the following carbocations in order from least to most stable. First, expand the structures to show all of the carbon and hydrogen atoms, at least in the vicinity of the charge. +
1) Draw 2 different structures that contain carbocations that would undergo a methyl shift a ring expansion Use arrows to show how this would occur