22.39 Propose an efficient synthesis for each of the following compounds using theacetoacetic ester synthesis:(a)(c)(b)0:(d)

Step 1:• The acidic proton of the Acetoacetic ester is abstract by strong base followed by attack on…

Answered: 22.39 Propose an efficient synthesis…

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter28: Biomolecules: Nucleic Acids

Section28.SE: Something Extra

Problem 38AP

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19.42 Although codeine occurs in low concentration in the opium poppy, most of the codeine used in medicine is prepared from morphine (the principal component of opium) by the following reaction. Explain why selective methylation occurs at only one OH in morphine to give codeine. Codeine is a less potent and less addictive analgesic than morphine. HO HO morphine N [1] KOH [2] CH₂I wwwwww HO codeine N
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Show the steps in preparing each of the following substances using either a malonic ester synthesis or an acetoacetic ester synthesis: (a) (b)

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22.39 Propose an efficient synthesis for each of the following compounds using the acetoacetic ester synthesis: (a) (c) (b) 0: (d)