Medical Case #1: DehydrationRaphael, in his third-year medical internship, was alone in the hospital emergency room (ER) onenight. It was unusually quiet in the ER, so the resident doctors were getting some much-neededsleep. A patient, Ms. Rose, was brought in showing signs of serious dehydration. Raphael triedto give her water but she vomited. Feeling that he must try something else and not wanting towake the residents, he administered 1 liter (L) of sterile distilled water intravenously (IV).Assume for simplicity that red blood cells (RBC) contain only solutes to which the RBC membraneis impermeable. The osmolarity of the RBC is 300 mOsm/L. 2. The volume of Ms. Rose's plasma was 3 L before Raphael administered the IV. Assumethat there was complete mixing of the administered water with her plasma but no mixingwith her interstitial fluid. Calculate Ms. Rose's plasma osmolarity after the infusion mixedwith her plasma but before any water entered her RBC.3. Assume that Ms. Rose's RBC volume was 2 L before the IV was given. Calculate herplasma and RBC osmolarity after the infused water equilibrated between her plasma andher RBC. How much would her RBC volume change? (Assume there was no mixing withher interstitial fluid.)4. The resident physician, knowing what Raphael had done, infused the patient with 1 L of a600 mM (i.e. 600 mOsm/L) sucrose solution. Assume that this infusion equilibrated withMs. Emily's plasma and RBC. Predict the effect of the infusion given by the resident.Explain.ParameterMs. Rose's RBC osmolarityMs. Rose's RBC volumePrediction

Introduction Osmosis is the process by which water molecules pass through a cell's partly permeable…

Answered: 2. The volume of Ms. Rose's plasma was…

Human Anatomy & Physiology (11th Edition)

11th Edition

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Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

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Medical Case #1: Dehydration
Raphael, in his third-year medical internship, was alone in the hospital emergency room (ER) one
night. It was unusually quiet in the ER, so the resident doctors were getting some much-needed
sleep. A patient, Ms. Rose, was brought in showing signs of serious dehydration. Raphael tried
to give her water but she vomited. Feeling that he must try something else and not wanting to
wake the residents, he administered 1 liter (L) of sterile distilled water intravenously (IV).
Assume for simplicity that red blood cells (RBC) contain only solutes to which the RBC membrane
is impermeable. The osmolarity of the RBC is 300 mOsm/L.

2. The volume of Ms. Rose's plasma was 3 L before Raphael administered the IV. Assume
that there was complete mixing of the administered water with her plasma but no mixing
with her interstitial fluid. Calculate Ms. Rose's plasma osmolarity after the infusion mixed
with her plasma but before any water entered her RBC.
3. Assume that Ms. Rose's RBC volume was 2 L before the IV was given. Calculate her
plasma and RBC osmolarity after the infused water equilibrated between her plasma and
her RBC. How much would her RBC volume change? (Assume there was no mixing with
her interstitial fluid.)
4. The resident physician, knowing what Raphael had done, infused the patient with 1 L of a
600 mM (i.e. 600 mOsm/L) sucrose solution. Assume that this infusion equilibrated with
Ms. Emily's plasma and RBC. Predict the effect of the infusion given by the resident.
Explain.
Parameter
Ms. Rose's RBC osmolarity
Ms. Rose's RBC volume
Prediction

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