2. The organization of DNA requires that replication be performed by a large “machine of proteins." What are the main proteins/enzymes associated with DNA replication and what is the function of EACH?

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### DNA Replication: Essential Proteins and Their Functions

**2. The organization of DNA requires that replication be performed by a large "machine of proteins." What are the main proteins/enzymes associated with DNA replication and what is the function of EACH?**

In the process of DNA replication, several key proteins and enzymes work together to ensure accurate and efficient duplication of the genetic material. Here, we explore the main participants in this complex cellular machinery:

1. **Helicase**: This enzyme unwinds the DNA double helix, creating two single strands that serve as templates for replication.

2. **Single-Strand Binding Proteins (SSBs)**: These proteins stabilize the unwound DNA strands, preventing them from re-annealing or forming secondary structures.

3. **Topoisomerase**: This enzyme prevents the overwinding or tangling of DNA ahead of the replication fork by creating temporary nicks in the DNA strand.

4. **Primase**: Synthesizes short RNA primers that provide a starting point for DNA synthesis by DNA polymerase.

5. **DNA Polymerase**: The main enzyme responsible for adding nucleotides to the growing DNA strand, following the complementary base-pairing rules.

6. **Sliding Clamp**: A protein that holds DNA polymerase in place on the DNA strand, ensuring high processivity during replication.

7. **RNase H**: Removes RNA primers after the new DNA strand is synthesized.

8. **DNA Ligase**: Seals the gaps between Okazaki fragments on the lagging strand, creating a continuous DNA strand.

Each of these proteins plays a critical role in ensuring that DNA replication is completed accurately and efficiently, maintaining the integrity of the genetic information passed on to daughter cells.
Transcribed Image Text:### DNA Replication: Essential Proteins and Their Functions **2. The organization of DNA requires that replication be performed by a large "machine of proteins." What are the main proteins/enzymes associated with DNA replication and what is the function of EACH?** In the process of DNA replication, several key proteins and enzymes work together to ensure accurate and efficient duplication of the genetic material. Here, we explore the main participants in this complex cellular machinery: 1. **Helicase**: This enzyme unwinds the DNA double helix, creating two single strands that serve as templates for replication. 2. **Single-Strand Binding Proteins (SSBs)**: These proteins stabilize the unwound DNA strands, preventing them from re-annealing or forming secondary structures. 3. **Topoisomerase**: This enzyme prevents the overwinding or tangling of DNA ahead of the replication fork by creating temporary nicks in the DNA strand. 4. **Primase**: Synthesizes short RNA primers that provide a starting point for DNA synthesis by DNA polymerase. 5. **DNA Polymerase**: The main enzyme responsible for adding nucleotides to the growing DNA strand, following the complementary base-pairing rules. 6. **Sliding Clamp**: A protein that holds DNA polymerase in place on the DNA strand, ensuring high processivity during replication. 7. **RNase H**: Removes RNA primers after the new DNA strand is synthesized. 8. **DNA Ligase**: Seals the gaps between Okazaki fragments on the lagging strand, creating a continuous DNA strand. Each of these proteins plays a critical role in ensuring that DNA replication is completed accurately and efficiently, maintaining the integrity of the genetic information passed on to daughter cells.
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