2. The following compound is used to treat lung carcinomas. The drug inhibits a kinase by forming a covalent bond with a specific amino acid residue. The electrophilic portion of the drug is referred to as a 'warhead' NH a. The drug reacts by a conjugate addition reaction. Identify and circle the 'warhead'. b. Draw the electrophilic portion of the molecule (the warhead) and attach it to an R1 that represents the rest of the molecule. Use this representation for the next part. c. Assume the molecule reacts with a cysteine residue. Use R2SH to represent Cys and draw arrow pushing mechanism for the reaction between Cys and the warhead. d. Draw the final product.

I need help with predicting the ester.

Can you please give an explanation for question 2( A to J)? Thank you

1. Which breaks down more quickly in an aqueous solution? DNA RNA

4. Draw the Falkin-Ahn model for the addition of LiAlH4 to the ketone shown below. Use the model to determine which diastereomer will form. Draw the major product. LIAIH4

Estrogens are female sex hormones, the most potent of which is B-estradiol. OH AYA Но B-Estradiol In recent years, chemists have focused on designing and synthesizing molecules that bind to estrogen receptors. One target of this research has been nonsteroidal estrogen antagonists, compounds that interact with estrogen receptors and block the effects of both endogenous and exogenous estrogens. A feature common to one type of nonste- roidal estrogen antagonist is the presence of a 1,2-diphenylethylene with one of the benzene rings bearing a dialkylaminoethoxyl substituent. The first nonsteroidal estrogen antagonist of this type to achieve clinical importance was tamoxifen, now an important drug in the treatment of breast cancer. Tamoxifen has the Z configuration shown here. NMeg A B NMeg ? ОН Tamoxifen Propose reagents for the conversion of A to tamoxifen. Note: The final step in this synthesis gives a mixture of E and Z isomers.

S-adenosylmethionine reacts with norepinephrine to form epinephrine. : OH sor :5: HO HO norepinephrine HO HO :5: Draw curved arrows to show the first step of the mechanism. Do not alter the pre-drawn structures. HO S-adenosylmethionine NH₂ : OH —s: NH₂ НО, HO : ÖH epinephrine OH N NH₂ N:

Draw the major product of this reaction. Ignore inorganic byproducts and the amine side product.

ol de C 3. Caffeine is an alkaloid, meaning alkali- or base-like. Circle functional groups in the molecule which would make react as a base. CH3 CH3 a. O b. O 4. Write the equations that account for what happens in the hydrolysis of acetamide O || (CH₂C-NH₂) in (a) acid and in (b) base. woled mode) N I T CH3 H Caffeine custom page 114

please help with all parts of this question. DOUBLE CHECK YOUR ANSWERS AS PREVIOUS TUTORS GOT IT WRONG.