2. The following compound is used to treat lung carcinomas. The drug inhibits a kinase by forming a covalent bond with a specific amino acid residue. The electrophilic portion of the drug is referred to as a 'warhead' NH a. The drug reacts by a conjugate addition reaction. Identify and circle the 'warhead'. b. Draw the electrophilic portion of the molecule (the warhead) and attach it to an R1 that represents the rest of the molecule. Use this representation for the next part. c. Assume the molecule reacts with a cysteine residue. Use R2SH to represent Cys and draw arrow pushing mechanism for the reaction between Cys and the warhead. d. Draw the final product.

1. Which breaks down more quickly in an aqueous solution? DNA RNA

Draw the structure of the major organic product(s) of the reaction. ممله + H30* • You do not have to consider stereochemistry. • All carboxyl and amino groups should be drawn in the neutral form. • Draw one structure per sketcher. Add additional sketchers using the drop-down menu in the bottom right corner. Separate multiple products using the + sign from the drop-down menu.

ANSWER FROM THE OPTIONS A.This drug may likely bind to what protein?Alphaglycoprotein , Bilirubin , Albumin,Globulin B.What is the IUPAC name of this compound? Octanoic acid ,2 – propylpentanoic acid ,1 – butylbutanoic acid ,2 – methylheptanoic acid C. this drug may likely affects what neurotransmitter? Norepinephrine ,Gamma amino butyric acid   ,Glutamate , Dopamine D.this drug affects what type of ion gated channel?, Sodium, Potassium, Calcium, Both A and B, Both A and C, Both B and C E.The drug is a powerful ? Antiparkinsonism, Anticonvulsant ,Antipsychotic , Antidepressant

1. Biogenic Amines are inactivated primarily by a. Sulfonation  b. Glucoronidation  c. Aromatic hydroxylation d. Methylation   2. A drug can exert its pharmacological effect only if it is   a. Protein bound  b. Protein unbound  c. Free drug d. Both B & C e. Both A & C   3. In order for the drug to be ready and available for absorption, it must be release first from its dosage form with the exception of:   a. Capsule b. Tablet c. Solution d. Suspension 4. All of the following are true, except a. Solubility increase with decrease particle size b. Solubility increase with increase surface area c. Solubility increase with increase particle size d. Solubility decrease with decrease surface area 5. The rate in which the drug appears in the bloodstream is also known as a. Half-life b. Potency c. Bioavailability d. Area under the curve

CHOICES: Physical Agent 2. Base Analogs 3. Alkylating Agent 4. Intercalating Agent 5. Metal ions 6. Biological Agent       Similar to the bases of DNA or chemicals that have a structural resemblance to the DNA bases 123456 Disrupt DNA structures and can cause frameshift mutation 123456 Denatures DNA and causes breakage or cleavage of the phosphodiester bonds through heat 123456 Induces the base-pairing errors that increases the ionization and production of gaps in the strand of the DNA. 123456 Producing ROS (reactive oxygen species), hindering the DNA repair pathway. 123456 Non-coding DNA sequences, jumps from one place to another place in a genome and influence the function of genes. 123456 Ethylnitrosourea 123456 Causes cross-linking and generation of nucleotide dimers. 123456 Able to hotwire our DNA make up and cause disease by expressing genes that causes abnormal production…

9. How do you know if a malenimide based reagent will conjugate to nitrogen or sulphur in an amino acid? но protein -protein SH NH2

1. Fill In the blank with the correct terms. a. Term for elemental cations that act as enzymatic cofactors. Tem for small organic molecules that act as enzymatic cofactors b. C. Part of the enzyme were chemical reactions occur. An enzyme that has multiple sites, some for reactions and others for reaction feedback control. Enzymes that are rather aggressive, and turned "off" by a protein segment untl they are activated. N a earch hp d. ai

Can you please answer questions 37 and 38?

Draw structural formulas for the two compounds you could use to prepare the amine shown by reductive amination. NH2 • You do not have to consider stereochemistry. • Do not include the reducing agent in your answer. • If there is more than one combination, draw only one. • Draw one structure per sketcher. Add additional sketchers using the drop-down menu in the bottom right corner. • Separate multiple reactants using the + sign from the drop-down menu. opy Bste [F ChemDoodle