2. The following compound is used to treat lung carcinomas. The drug inhibits a kinase by forming a covalent bond with a specific amino acid residue. The electrophilic portion of the drug is referred to as a 'warhead' NH a. The drug reacts by a conjugate addition reaction. Identify and circle the 'warhead'. b. Draw the electrophilic portion of the molecule (the warhead) and attach it to an R1 that represents the rest of the molecule. Use this representation for the next part. c. Assume the molecule reacts with a cysteine residue. Use R2SH to represent Cys and draw arrow pushing mechanism for the reaction between Cys and the warhead. d. Draw the final product.

can you help with 14 as well?

Q19 In order to find bactericidal antibiotics – substances that can selectively kill bacteria without harming human cells, a combinatorial library was screened in 96 well plates. Which of the five compounds (I - V) is the most likely to be a bactericidal antibiotic? Choose one answer only. | || ||| IV v Bacterial cells and compounds Bacterial cells only Human cells and compound Human cells only a. V b. III c. II d. I cell growth no cell growth

Predict the most likely product of this biochemical reaction: CH₂= OH O + Pi X + H₂O That is, in the drawing area below, draw the chemical structure of the product molecule X. Note for advanced students: you can assume any necessary small-molecule reactants, like water, are available. Predicting reactants or products of phosphorylation Click and drag to start drawing a structure. X Ś (

1. Which breaks down more quickly in an aqueous solution? DNA RNA

S-adenosylmethionine reacts with norepinephrine to form epinephrine. : OH sor :5: HO HO norepinephrine HO HO :5: Draw curved arrows to show the first step of the mechanism. Do not alter the pre-drawn structures. HO S-adenosylmethionine NH₂ : OH —s: NH₂ НО, HO : ÖH epinephrine OH N NH₂ N:

need help please and thanks dont understand a-b Learning Goal: As discussed during the lecture, the enzyme HIV-1 reverse transcriptae (HIV-RT) plays a significant role for the HIV virus and is an important drug target. Assume a concentration [E] of 2.00 µM (i.e. 2.00 x 10-6 mol/l) for HIV-RT. Two potential drug molecules, D1 and D2, were identified, which form stable complexes with the HIV-RT. The dissociation constant of the complex ED1 formed by HIV-RT and the drug D1 is 1.00 nM (i.e. 1.00 x 10-9). The dissociation constant of the complex ED2 formed by HIV-RT and the drug D2 is 100 nM (i.e. 1.00 x 10-7).   Part A - Difference in binding free eenergies Compute the difference in binding free energy (at a physiological temperature T=310 K) for the complexes. Provide the difference as a positive numerical expression with three significant figures in kJ/mol. The margin of error is 2%.   Part B - Compare difference in free energy to the thermal energy Divide the…

Lit CH3I LDA) CH3I C12 Hcl /H2O LDA 2) Br

e) OH ४ starting material target compound

The following chemical equation is for an elimination reaction, where the important atoms, groups, and bonds involved have been highlighted for you: Η Η CI H DBU ? + H-CI Use the information provided to predict the missing organic product and draw its structure in the drawing area below. Make sure to use the same skeletal ("line") style for the structure as the rest of the equation. Click and drag to start drawing a structure. X 0:0 S sm