2. In a large clinic located in an inner city hospital, 56 patients with non- symptomatic HIV infection have been treated with an experimental drug believed to have the capability of restoring certain immune system functions associated with HIV infection. Of these patients, 12 had CD4 cell counts below 250 at the initial visit, 20 had counts between 250 and 400, and 24 had counts above 400. (The lower the count, the worse the prognosis.) It is desired to take a stratified random sample of 30 patients, 10 from each of the three groups described above, for purposes of estimating the 12-month incidence of AIDS-defining events among these patients. The results of this sample survey are shown below: 1

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2. In a large clinic located in an inner city hospital, 56 patients with non-
symptomatic HIV infection have been treated with an experimental drug believed
to have the capability of restoring certain immune system functions associated
with HIV infection. Of these patients, 12 had CD4 cell counts below 250 at the
initial visit, 20 had counts between 250 and 400, and 24 had counts above 400.
(The lower the count, the worse the prognosis.) It is desired to take a stratified
random sample of 30 patients, 10 from each of the three groups described
above, for purposes of estimating the 12-month incidence of AIDS-defining
events among these patients. The results of this sample survey are shown
below:
Number of Persons
CD4 Level
250-399
2
2
0
a. How many samples of 30 patients taken as described above are possible?
b. Estimate the proportion of patients having one or more AIDS-defining
events.
c. What is the estimated standard error of this estimated proportion?
d. A simple random sample (without stratification) of 30 of these patients
yielded the following data:
Number of Events
0
123
Number of Events
0
123
2
< 250
6722N
5
1
1
< 250
3
1
0
2
Number of Persons
CD4 Level
250-399
8
2
1
0
400 and Over
9
1
O
400 and Over
12
0
1
0
i. How many samples of size 30 are possible under simple random
sampling without stratification?
ii. Estimate the incidence of AIDS-defining events from these data
and the estimated standard error of this estimated proportion.
iii. Compare this with the results obtained from the stratified sampling
design. Which design produces the more reliable estimate? Why
does it?
Transcribed Image Text:2. In a large clinic located in an inner city hospital, 56 patients with non- symptomatic HIV infection have been treated with an experimental drug believed to have the capability of restoring certain immune system functions associated with HIV infection. Of these patients, 12 had CD4 cell counts below 250 at the initial visit, 20 had counts between 250 and 400, and 24 had counts above 400. (The lower the count, the worse the prognosis.) It is desired to take a stratified random sample of 30 patients, 10 from each of the three groups described above, for purposes of estimating the 12-month incidence of AIDS-defining events among these patients. The results of this sample survey are shown below: Number of Persons CD4 Level 250-399 2 2 0 a. How many samples of 30 patients taken as described above are possible? b. Estimate the proportion of patients having one or more AIDS-defining events. c. What is the estimated standard error of this estimated proportion? d. A simple random sample (without stratification) of 30 of these patients yielded the following data: Number of Events 0 123 Number of Events 0 123 2 < 250 6722N 5 1 1 < 250 3 1 0 2 Number of Persons CD4 Level 250-399 8 2 1 0 400 and Over 9 1 O 400 and Over 12 0 1 0 i. How many samples of size 30 are possible under simple random sampling without stratification? ii. Estimate the incidence of AIDS-defining events from these data and the estimated standard error of this estimated proportion. iii. Compare this with the results obtained from the stratified sampling design. Which design produces the more reliable estimate? Why does it?
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