2. Hemoglobin mutants (Answers to this question won't be posted – discussed in Discussion.) A. For a mutant in which the T-R equilibrium is shifted toward the R state, what type of change would you expect in P50? (Would the P50 for the mutant be higher or lower than normal HbA?) Does that mean O2 affinity of mutant is higher or lower than normal? Sketch a normal HbA binding curve (sigmoid) and then sketch the curve you would expect for a mutant with T-R equilibrium shifted toward the R state.
2. Hemoglobin mutants (Answers to this question won't be posted – discussed in Discussion.) A. For a mutant in which the T-R equilibrium is shifted toward the R state, what type of change would you expect in P50? (Would the P50 for the mutant be higher or lower than normal HbA?) Does that mean O2 affinity of mutant is higher or lower than normal? Sketch a normal HbA binding curve (sigmoid) and then sketch the curve you would expect for a mutant with T-R equilibrium shifted toward the R state.
Human Anatomy & Physiology (11th Edition)
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2. Hemoglobin mutants (Answers to this question won't be posted - discussed in Discussion.)
A. For a mutant in which the T-R equilibrium is shifted toward the R state, what type of change would
you expect in P50? (Would the P50 for the mutant be higher or lower than normal HbA?)
Does that mean O2 affinity of mutant is higher or lower than normal?
Sketch a normal HbA binding curve (sigmoid) and then sketch the curve you would expect for a
mutant with T-R equilibrium shifted toward the R state.
Sch
Expert Solution
Step 1
In T-R equilibrium for a mutant, a shift towards the R state indicates an increase in oxygen affinity than normal. Thus P50 value will be lower than normal HbA.
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