2 um DNA strand Scaffold (a) Metaphase chromosome (b) Metaphase chromosome treated with high salt to remove histone proteins FIGURE 10.18 The importance of histone proteins and scaffolding proteins in the compaction of eukaryotic chromosomes. (a) A metaphase chromosome. (b) A metaphase chromosome following treatment with highly concentrated salt solution to remove the histone proteins. The black arrow on the right points to an elongated strand of DNA. The white arrow on the left points to the scaffold (composed of nonhistone proteins), which anchors the bases of the radial loops. As shown earlier in Figure 10.17d, this scaffold consists of protein filaments.

Human Anatomy & Physiology (11th Edition)
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ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Consider how histone proteins bind to DNA and then explain why
a high salt concentration can remove histones from DNA (as
shown in 10.18b).

2 um
DNA strand
Scaffold
(a) Metaphase chromosome
(b) Metaphase chromosome treated with high salt to remove histone proteins
FIGURE 10.18 The importance of histone proteins and scaffolding proteins in the compaction of eukaryotic chromosomes. (a) A metaphase
chromosome. (b) A metaphase chromosome following treatment with highly concentrated salt solution to remove the histone proteins. The black arrow on
the right points to an elongated strand of DNA. The white arrow on the left points to the scaffold (composed of nonhistone proteins), which anchors the
bases of the radial loops. As shown earlier in Figure 10.17d, this scaffold consists of protein filaments.
Transcribed Image Text:2 um DNA strand Scaffold (a) Metaphase chromosome (b) Metaphase chromosome treated with high salt to remove histone proteins FIGURE 10.18 The importance of histone proteins and scaffolding proteins in the compaction of eukaryotic chromosomes. (a) A metaphase chromosome. (b) A metaphase chromosome following treatment with highly concentrated salt solution to remove the histone proteins. The black arrow on the right points to an elongated strand of DNA. The white arrow on the left points to the scaffold (composed of nonhistone proteins), which anchors the bases of the radial loops. As shown earlier in Figure 10.17d, this scaffold consists of protein filaments.
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