2 um DNA strand Scaffold (a) Metaphase chromosome (b) Metaphase chromosome treated with high salt to remove histone proteins FIGURE 10.18 The importance of histone proteins and scaffolding proteins in the compaction of eukaryotic chromosomes. (a) A metaphase chromosome. (b) A metaphase chromosome following treatment with highly concentrated salt solution to remove the histone proteins. The black arrow on the right points to an elongated strand of DNA. The white arrow on the left points to the scaffold (composed of nonhistone proteins), which anchors the bases of the radial loops. As shown earlier in Figure 10.17d, this scaffold consists of protein filaments.
Gene Interactions
When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
Consider how histone proteins bind to DNA and then explain why
a high salt concentration can remove histones from DNA (as
shown in 10.18b).
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