2) The molecule below has at least 4 possible retrosynthesis disconnections based on chemistry you know. a. i) Find the four different disconnections, and show the two fragments for each. ii) Provide the name/type of reaction corresponding to each disconnection. iii) Do you notice any problem with any of the disconnections? Explain. iv) Which choice(s) would be the best? b. Using the disconnection approach you chose, show a complete synthesis of the target molecule starting from hydroquinone, benzyl alcohol, or anything else with six or less carbon atoms. Ph

2) The molecule below has at least 4 possible retrosynthesis disconnections based on chemistry you know. a. i) Find the four different disconnections, and show the two fragments for each. ii) Provide the name/type of reaction corresponding to each disconnection. iii) Do you notice any problem with any of the disconnections? Explain. iv) Which choice(s) would be the best? b. Using the disconnection approach you chose, show a complete synthesis of the target molecule starting from hydroquinone, benzyl alcohol, or anything else with six or less carbon atoms. Ph

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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2. Answer the questions about the E2 reaction shown below. NaOMe A. What regioisomer will predominate in this reaction, the Zaitsev or Hofmann product? B. Draw a Newman projection of the substrate in the reactive conformer that leads to the major product. C. Draw an arrow mechanism for the E2 reaction with the substrate in the appropriate conformation that will produce the product that you indicated in part A. D. Based on your answer to parts A-C, draw the correct regio- and stereoisomer of the product in the space provided. E. Provide a systematic name of the substrate. F. Provide a systematic name of the product (see section 8.3 for alkene nomenclature). G. Draw a transition state structure of the reaction with partial bonds and partial charges indicated. H. Draw an energy diagram for the E2 reaction on the previous page. Your reaction coordinate diagram should: Include structures of starting materials, products, and transition states at correct relative energies. Indicate the…
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