1x GGCGAUGGGCAAUAAACCGGGCCAGUAAGC Identify the start codon, and determine the complete amino acid sequence that would be translated from this mRNA. 2. What does it mean when we say that the genetic code is (a) degenerate and (b) nonoverlapping? 3. How many different sequences of mRNA could encode a peptide with the sequence proline-glycine- methionine-serine? Be sure to show your work. F2 4. A tRNA has the anticodon sequence 3'-CAG-5'. What amino acid does it carry? Illustrate how the anticodon of the tRNA interacts with its cognate codon on mRNA (you do not need to draw out the bases and their exact hydrogen bonding patterns; instead, you can just use the single letter abbreviations for the bases). Where is the anticodon located in the tRNA molecule? Where is the amino acid attached to the tRNA? Your illustration can include the overall general structure of a tRNA to address these questions. 5. What is the role of aminoacyl-tRNA synthetase? The ability of aminoacyl-tRNA synthetases to recognize tRNAs has sometimes been called the "second genetic code." Why has the unction of this enzyme been described this way? 6. For each of the following initiation factors (refer to the powerpoint slides), how would eukaryotic initiation of translation be affected if it were missing? #0 3 E D (a) elF2 (b) elF4 (c) elF5 7. Explain the functional roles of the A, P and E sites of a ribosome during translation. 8. Describe the mechanism of action for the following antibiotics on translation (a) Chloramphenicol (b) Erythromycin (c) Puromycin (d) Tetracycline (e) Streptomycin $ 4 R F F4 DII % 5 T G FS * A 6 F6 Y H * F7 & 7 U J PrtScn FB *00 8 I Home F9 K ( 9 I End O F10 L ) 0 PgUp P F11 T PgDn { F12 [ + = } Ins 1 953 PM 10/12/2022 Del Backspace T
1x GGCGAUGGGCAAUAAACCGGGCCAGUAAGC Identify the start codon, and determine the complete amino acid sequence that would be translated from this mRNA. 2. What does it mean when we say that the genetic code is (a) degenerate and (b) nonoverlapping? 3. How many different sequences of mRNA could encode a peptide with the sequence proline-glycine- methionine-serine? Be sure to show your work. F2 4. A tRNA has the anticodon sequence 3'-CAG-5'. What amino acid does it carry? Illustrate how the anticodon of the tRNA interacts with its cognate codon on mRNA (you do not need to draw out the bases and their exact hydrogen bonding patterns; instead, you can just use the single letter abbreviations for the bases). Where is the anticodon located in the tRNA molecule? Where is the amino acid attached to the tRNA? Your illustration can include the overall general structure of a tRNA to address these questions. 5. What is the role of aminoacyl-tRNA synthetase? The ability of aminoacyl-tRNA synthetases to recognize tRNAs has sometimes been called the "second genetic code." Why has the unction of this enzyme been described this way? 6. For each of the following initiation factors (refer to the powerpoint slides), how would eukaryotic initiation of translation be affected if it were missing? #0 3 E D (a) elF2 (b) elF4 (c) elF5 7. Explain the functional roles of the A, P and E sites of a ribosome during translation. 8. Describe the mechanism of action for the following antibiotics on translation (a) Chloramphenicol (b) Erythromycin (c) Puromycin (d) Tetracycline (e) Streptomycin $ 4 R F F4 DII % 5 T G FS * A 6 F6 Y H * F7 & 7 U J PrtScn FB *00 8 I Home F9 K ( 9 I End O F10 L ) 0 PgUp P F11 T PgDn { F12 [ + = } Ins 1 953 PM 10/12/2022 Del Backspace T
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
Related questions
Question
Question 5
Transcribed Image Text:1. AR MRNA has the following sequence:
GGCGAUGGGCAAUAAACCGGGCCAGUAAGC
1x
Identify the start codon, and determine the complete amino acid sequence that would be translated from
this mRNA.
2. What does it mean when we say that the genetic code is (a) degenerate and (b) nonoverlapping?
3. How many different sequences of mRNA could encode a peptide with the sequence proline-glycine-
methionine-serine? Be sure to show your work.
F2
4. A tRNA has the anticodon sequence 3'-CAG-5'. What amino acid does it carry? Illustrate how the
anticodon of the tRNA interacts with its cognate codon on mRNA (you do not need to draw out the bases
and their exact hydrogen bonding patterns; instead, you can just use the single letter abbreviations for the
bases). Where is the anticodon located in the tRNA molecule? Where is the amino acid attached to the
tRNA? Your illustration can include the overall general structure of a tRNA to address these questions.
5. What is the role of aminoacyl-tRNA synthetase? The ability of aminoacyl-tRNA synthetases to recognize
tRNAs has sometimes been called the "second genetic code." Why has the unction of this enzyme been
described this way?
6. For each of the following initiation factors (refer to the powerpoint slides), how would eukaryotic initiation of
translation be affected if it were missing?
#
3
E
D
(a) elF2
(b) elF4
(c) elF5
7. Explain the functional roles of the A, P and E sites of a ribosome during translation.
8. Describe the mechanism of action for the following antibiotics on translation
(a) Chloramphenicol
(b) Erythromycin
4,
F3
(c) Puromycin
(d) Tetracycline
(e) Streptomycin
(11)
$
4
R
F
F4
H
DII
%
5
T
G
F5
B
*
A
6
F6
Y
H
*
N
F7
&
7
U
J
PrtScn
F8
8
C
M
Home
K
F9
(
9
O
End
F10
L
)
0
PgUp
F11
P
18
PgDn
F12
....
?
+
=
Ins
9:53 PM
10/12/2022
Del
Backspace
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