Please solve and explain? **Problem 19:** Demonstrate the synthesis of 4-methyl-3-hexanol from 3-pentanone.**Explanation:**The task is to outline a synthetic route from 3-pentanone, a ketone, to 4-methyl-3-hexanol, an alcohol. The process will likely involve:1. **Grignard Reaction:** This involves the formation of a Grignard reagent from an alkyl halide, which will add to the carbonyl group of 3-pentanone.2. **Reduction:** The intermediate product may need to undergo a reduction to convert the ketone group into an alcohol.The detailed steps include:- **Step 1:** Prepare the Grignard Reagent. Choose an appropriate alkyl halide, which, when reacted with magnesium, forms the Grignard reagent.- **Step 2:** React the Grignard reagent with 3-pentanone to form the tertiary alcohol after rearrangement.- **Step 3:** An acidic work-up might be necessary to ensure the formation of the desired alcohol product.### Potential Challenges- **By-product Formation:** Careful control of reaction conditions is required to avoid by-products that could complicate purification.- **Stereochemistry:** Ensure the correct stereochemistry if the product requires a specific configuration.### ConclusionThe synthesis of 4-methyl-3-hexanol from 3-pentanone involves strategic use of a Grignard reaction followed by reduction, demonstrating key concepts in organic chemistry such as nucleophilic addition and reduction of carbonyl groups.

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Answered: 19. Show how 4-methyl-3-hexanol can be…

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19. Show how 4-methyl-3-hexanol can be synthesized from 3-pentanone.

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

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Concept explainers

Designing a Synthesis

Organic synthesis is a branch of chemical synthesis that involves the planned construction of organic compounds/molecules from smaller units that possess functional groups. Friedrich Wöhler was the first scientist who designed the synthesis of an organic compound, urea from inorganic starting materials silver cyanate with ammonium chloride via a simple, one-step synthesis.

Question

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Please solve and explain?

**Problem 19:** Demonstrate the synthesis of 4-methyl-3-hexanol from 3-pentanone.

**Explanation:**

The task is to outline a synthetic route from 3-pentanone, a ketone, to 4-methyl-3-hexanol, an alcohol. The process will likely involve:

1. **Grignard Reaction:** This involves the formation of a Grignard reagent from an alkyl halide, which will add to the carbonyl group of 3-pentanone.
2. **Reduction:** The intermediate product may need to undergo a reduction to convert the ketone group into an alcohol.

The detailed steps include:

- **Step 1:** Prepare the Grignard Reagent. Choose an appropriate alkyl halide, which, when reacted with magnesium, forms the Grignard reagent.
- **Step 2:** React the Grignard reagent with 3-pentanone to form the tertiary alcohol after rearrangement.
- **Step 3:** An acidic work-up might be necessary to ensure the formation of the desired alcohol product.

### Potential Challenges

- **By-product Formation:** Careful control of reaction conditions is required to avoid by-products that could complicate purification.
- **Stereochemistry:** Ensure the correct stereochemistry if the product requires a specific configuration.

### Conclusion

The synthesis of 4-methyl-3-hexanol from 3-pentanone involves strategic use of a Grignard reaction followed by reduction, demonstrating key concepts in organic chemistry such as nucleophilic addition and reduction of carbonyl groups.

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