Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Transcribed Image Text:**Exercise 17: Assign the R/S Configuration to Chiral Centers**
In this exercise, you are tasked with assigning the R/S configuration to each chiral center in the molecules provided. If you find it challenging to visualize, consider building a molecular model to assist with visualization.
**Molecules provided:**
1. **Molecule 1:**
- Contains a chiral center with a bromine (Br) substituent.
2. **Molecule 2:**
- A chiral center connected to an amine group (NH₂).
3. **Molecule 3:**
- Features a chiral center with an alcohol (OH) group in a cyclopentane ring.
4. **Molecule 4:**
- Another chiral center associated with a bromine (Br) atom and a secondary hydrogen (H).
5. **Molecule 5:**
- Displays a chiral center bonded to an alcohol (OH) group and hydrogen (H).
6. **Molecule 6:**
- Contains fluorine (F) and hydrogen (H) at the chiral center within a bicyclic structure.
7. **Molecule 7:**
- Features chiral centers with chlorine (Cl) and bromine (Br) substituents.
**Guidance on R/S Configuration:**
- Assign priorities to the substituents based on atomic number (the higher the atomic number, the higher the priority).
- Orient the molecule so that the lowest priority substituent is directed away from you.
- Determine the order of the remaining substituents: clockwise indicates R configuration, and counterclockwise indicates S configuration.
This exercise challenges you to consider spatial arrangement and priority rules in stereochemistry, crucial for understanding molecular interactions in various chemical reactions and biological systems.
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