17. Assign the R/S configuration to each chiral center below. If you have difficulty, try building a molecule. он Br H NH2 Br F Br

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**Exercise 17: Assign the R/S Configuration to Chiral Centers**

In this exercise, you are tasked with assigning the R/S configuration to each chiral center in the molecules provided. If you find it challenging to visualize, consider building a molecular model to assist with visualization.

**Molecules provided:**

1. **Molecule 1:** 
   - Contains a chiral center with a bromine (Br) substituent.

2. **Molecule 2:**
   - A chiral center connected to an amine group (NH₂).

3. **Molecule 3:**
   - Features a chiral center with an alcohol (OH) group in a cyclopentane ring.

4. **Molecule 4:**
   - Another chiral center associated with a bromine (Br) atom and a secondary hydrogen (H).

5. **Molecule 5:**
   - Displays a chiral center bonded to an alcohol (OH) group and hydrogen (H).

6. **Molecule 6:**
   - Contains fluorine (F) and hydrogen (H) at the chiral center within a bicyclic structure.

7. **Molecule 7:**
   - Features chiral centers with chlorine (Cl) and bromine (Br) substituents.

**Guidance on R/S Configuration:**
- Assign priorities to the substituents based on atomic number (the higher the atomic number, the higher the priority).
- Orient the molecule so that the lowest priority substituent is directed away from you.
- Determine the order of the remaining substituents: clockwise indicates R configuration, and counterclockwise indicates S configuration.

This exercise challenges you to consider spatial arrangement and priority rules in stereochemistry, crucial for understanding molecular interactions in various chemical reactions and biological systems.
Transcribed Image Text:**Exercise 17: Assign the R/S Configuration to Chiral Centers** In this exercise, you are tasked with assigning the R/S configuration to each chiral center in the molecules provided. If you find it challenging to visualize, consider building a molecular model to assist with visualization. **Molecules provided:** 1. **Molecule 1:** - Contains a chiral center with a bromine (Br) substituent. 2. **Molecule 2:** - A chiral center connected to an amine group (NH₂). 3. **Molecule 3:** - Features a chiral center with an alcohol (OH) group in a cyclopentane ring. 4. **Molecule 4:** - Another chiral center associated with a bromine (Br) atom and a secondary hydrogen (H). 5. **Molecule 5:** - Displays a chiral center bonded to an alcohol (OH) group and hydrogen (H). 6. **Molecule 6:** - Contains fluorine (F) and hydrogen (H) at the chiral center within a bicyclic structure. 7. **Molecule 7:** - Features chiral centers with chlorine (Cl) and bromine (Br) substituents. **Guidance on R/S Configuration:** - Assign priorities to the substituents based on atomic number (the higher the atomic number, the higher the priority). - Orient the molecule so that the lowest priority substituent is directed away from you. - Determine the order of the remaining substituents: clockwise indicates R configuration, and counterclockwise indicates S configuration. This exercise challenges you to consider spatial arrangement and priority rules in stereochemistry, crucial for understanding molecular interactions in various chemical reactions and biological systems.
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