11. Which of the following best describes what happens when hemoglobin bindsbisphosphoglyceric acid (BPG)?A. Binding of BPG leads to tighter binding of oxygen.B. Binding of BPG allows maternal (adult) Hb to bind oxygen more tightly than fetal Hb.C. Binding of BPG is important to the allosteric nature of hemoglobinD. Binding of BPG causes the subunits of hemoglobin to separate.

Hemoglobin is a globular protein, ie it is roughly spherical. It is a tetramer of two types of…

Answered: 11. Which of the following best…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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In mammals, the developing fetus obtains O₂ from its mother's blood via the placenta. For this to occur... A. The fetal hemoglobin must have a higher Pso than the maternal hemoglobin B. The O₂ equilibrium curve of the fetal hemoglobin must be left-shifted with respect to the curve for the maternal hemoglobin C. The maternal hemoglobin must have a higher O₂ binding affinity than the fetal hemoglobin D. The O₂ carrying capacity of the fetal hemoglobin must be greater than that of the maternal hemoglobin E. None of the above
Which of the following scenariosare correct?Select all that apply A. High levels of PCO2will cause loading of O2ontohemoglobin. B. An increase in pH will causeO2to unload from hemoglobin. C. High PO2levels will increase saturation of Hb with O2. D. An increase in bodytemperature will cause O2to unload from hemoglobin.
8. Researchers obtain a pure solution of antibodies that bind specifically to the cadherins (linking proteins) of the desmosomes of epithelial cells of a mouse. As a follow up of their previous experiment, they take a tube of individual muscle cells from a chicken and add antibodies to the tube. What is the predicted outcome of this second experiment? A. The antibodies will bind to the chicken muscle cells, so the cells will adhere to each other B. The antibodies will bind to the chicken muscle cells, so the muscle cells will not adhere to each other C. The antibodies will not bind to the chicken muscle cells, so the cells will adhere to each other D. The antibodies will not bind to the chicken muscle cells, so the cells will not adhere to each other
Based on your understanding of genetic code,explain the formation of any abnormal hemoglobin molecule?
Identify the human form of hemoglobin that is produced most abundantly in the adult.A. two -globin chains (alpha) and two -globin chains (beta)B. two -globin chains (beta) and two -globin chains (gamma)C. two -globin chains (gamma) and two -globin chains (delta)D. two -globin chains (delta) and two -globin chains (epsilon)E. two -globin chains (epsilon) and two -globin chains (zeta)
The Bohr effect related to A. the ability of Hb to bind 02 in the presence of BPG. the ability of myoglobin to expel protons when binding 02. B. the ability of Hb to "take up" protons when binding 02. C. the ability of Hb to release protons when binding O2. D. O E. BPG ionization at 30 torr (the pO2 in veins).
One of the following is NOT correct regards haptoglobin A. is a strong acute-phase protein, increases 1000-folds shortly after inflammation B. is α2-glycoprotein C. Prevents iron loss through the kidneys D. is decreased in liver disease and haemolytic anemia E. None of the above
Identify the human form of hemoglobin that is produced only by the embryo. two a-globin chains (alpha) and two b-globin chains (beta) two b-globin chains (beta) and two g-globin chains (gamma) two g-globin chains (gamma) and two d-globin chains (delta) two d-globin chains (delta) and two e-globin chains (epsilon) two e-globin chains (epsilon) and two z-globin chains (zeta)
12) The tertiary structure of immunoglobulin G is composed of 12 discrete: A. alpha-helices B. collapsed beta-barrel domains C. parallel beta-sheets D. helix-turn-helix domains
1.Describe the steps involved in the formation of Hemoglobin. 2. Diagram the structure of Hemoglobin
Suppose a hypothetical "molecule X" binds to hemoglobin (at a different site than the O2 binding site) and stabilizes the T state. How would you identify this effector? a. Positive homotropic effector b. Negative homotropic effector c. Positive heterotropic effector d. Negative heterotropic effector
Why is the decreased affinity of fetal hemoglobin for BPG advantageous? With fewer BPG molecules bound to heme, there are more heme residues available for O2 binding. O A. B. Decreased BPG binding biases the fetal hemoglobin toward the R state. C. More free BPG is available to bind to adult hemoglobin, resulting in a shift to the R state. BPG is more available to bind to fetal myoglobin. helping to release O2 in fetal muscle tissue. D. 47

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