1.1 Propose the reaction mechanism for the formation of the products formed in each of the reactions in the scheme below. Clearly show the stereochemistry of A and B and explain their formation. Ⓒ PPH3 @ PPH3 CHO NaH n-BuLi COMe MeO₂C A CHO 1.2 The reagent, (MeO)2P=O(CH₂CO2Me), is treated with sodium methoxide and the resultant species is then reacted with the following compound: CHO Give the product(s) of each step the reaction sequence. B
Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
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