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1. You have isolated 9 different mouse mutants that have developmental phenotypes associated with limb development (malformed limbs). To determine how many different genes are repsented in your 9 mutants, you generate true-breeding lines of each mutant. For all 9 mutants, when crossing a true-breeding mutant to true-breeding wildtype, the F1 are wildtype. Below is a complementation table summarizing the data of all the complementation test, where + = wiltype progeny and - = mutant progeny with malformed limbs. Mutants 1 1 2 3 4 5 6 7 8 9 + + - + + + + 2 + 1 + + + + + 1A. For mutant 2 and mutant 4: 3 + + + + + + + 4 I + + - + + + + 5 - + + + + + + 6 + + + + + + + + Do these two mutants complement or fail to complement? Are these mutant alleles of the same gene or different genes? 7 + - + + + + + 1B. How many different genes are represented across the 9 mutants? 8 + - + + + + - + 9 + + - + + + + +

1. You have isolated 9 different mouse mutants that have developmental phenotypes associated with limb development (malformed limbs). To determine how many different genes are repsented in your 9 mutants, you generate true-breeding lines of each mutant. For all 9 mutants, when crossing a true-breeding mutant to true-breeding wildtype, the F1 are wildtype. Below is a complementation table summarizing the data of all the complementation test, where + = wiltype progeny and - = mutant progeny with malformed limbs. Mutants 1 1 2 3 4 5 6 7 8 9 + + - + + + + 2 + 1 + + + + + 1A. For mutant 2 and mutant 4: 3 + + + + + + + 4 I + + - + + + + 5 - + + + + + + 6 + + + + + + + + Do these two mutants complement or fail to complement? Are these mutant alleles of the same gene or different genes? 7 + - + + + + + 1B. How many different genes are represented across the 9 mutants? 8 + - + + + + - + 9 + + - + + + + +

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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1. You have isolated 9 different mouse mutants that have developmental phenotypes associated with limb development (malformed limbs). To determine how many different genes are repsented in your 9 mutants, you generate true-breeding lines of each mutant. For all 9 mutants, when crossing a true-breeding mutant to true-breeding wildtype, the F1 are wildtype. Below is a complementation table summarizing the data of all the complementation test, where + = wiltype progeny and - mutant progeny with malformed limbs. Mutants 1 1 2 3 4 5 6 7 8 9 + + + + + + 2 + I + + + + I + 1A. For mutant 2 and mutant 4: 3 + + + + + + + 4 + + + + + + 5 6 + + I + + + + + + + + + Do these two mutants complement or fail to complement? Are these mutant alleles of the same gene or different genes? 7 + + + + + 1B. How many different genes are represented across the 9 mutants? 89 + + + + + - + + + + + + + +
Transcribed Image Text:1. You have isolated 9 different mouse mutants that have developmental phenotypes associated with limb development (malformed limbs). To determine how many different genes are repsented in your 9 mutants, you generate true-breeding lines of each mutant. For all 9 mutants, when crossing a true-breeding mutant to true-breeding wildtype, the F1 are wildtype. Below is a complementation table summarizing the data of all the complementation test, where + = wiltype progeny and - mutant progeny with malformed limbs. Mutants 1 1 2 3 4 5 6 7 8 9 + + + + + + 2 + I + + + + I + 1A. For mutant 2 and mutant 4: 3 + + + + + + + 4 + + + + + + 5 6 + + I + + + + + + + + + Do these two mutants complement or fail to complement? Are these mutant alleles of the same gene or different genes? 7 + + + + + 1B. How many different genes are represented across the 9 mutants? 89 + + + + + - + + + + + + + +
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