1. You have a glucose molecule that is radiolabeled at carbon 5.a). Indicate which carbon(s) in pyruvate would be radiolabeled:b). If pyruvate is converted to oxaloacetate through pyruvate carboxylase, indicate the labeling pattern on theCH,OHHH.OH HноH3C--cooонfirst isocitrate produced.ÇoOCH2HÇ-CoHO-CHc). Indicate the labeling pattern and distribution in oxaloacetate at the end of thisturn of the TCA cycle.:čooCooCH2d). What turn of the TCA cycle would label start to be lost as CO; (1 turn has been completed) ?e). Which carbon in pyruvate would have been labeled to give you the labeling pattern in part c, if that pyruvatewent through PDH and the TCA cycle, instead of pyruvate carboxylase.H3C-cof). How is the label in part c physically distributed on actual oxaloacetate molecules?

In glycolysis glucose converted to pyruvate via glycolysis.

1. You have a glucose molecule that is radiolabeled at carbon 5. a). Indicate which carbon(s) in pyruvate would be radiolabeled: b). If pyruvate is converted to oxaloacetate through pyruvate carboxylase, indicate the labeling pattern on the CH,OH H H. OH H но H3C- -coo он first isocitrate produced. CH2 HC -coo HO-CH čoo c). Indicate the labeling pattern and distribution in oxaloacetate at the end of this turn of the TCA cycle.: Coo CH2

1. You have a glucose molecule that is radiolabeled at carbon 5. a). Indicate which carbon(s) in pyruvate would be radiolabeled: b). If pyruvate is converted to oxaloacetate through pyruvate carboxylase, indicate the labeling pattern on the CH,OH H H. OH H но H3C- -coo он first isocitrate produced. CH2 HC -coo HO-CH čoo c). Indicate the labeling pattern and distribution in oxaloacetate at the end of this turn of the TCA cycle.: Coo CH2

Chemistry

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ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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Concept explainers

Organic Chemistry of Metabolic Pathways

Metabolic pathways allude to the arrangement of chemical catalyzed reactions that lead to the transformation of a substance into the final product. Metabolic pathways incorporate a progression of reaction where the substrate is changed continuously and the transitional metabolites are persistently recovered.

Glucogenesis

Glucogenesis is a metabolic pathway in which glucose is produced from carbon substrates that are not carbohydrates. This process is observed in plants, animals, fungi, bacteria and other micro organisms. The general definition for glucogenesis or gluconeogenesis is as follows,

Question

1. You have a glucose molecule that is radiolabeled at carbon 5.
a). Indicate which carbon(s) in pyruvate would be radiolabeled:
b). If pyruvate is converted to oxaloacetate through pyruvate carboxylase, indicate the labeling pattern on the
CH,OH
H
H.
OH H
но
H3C-
-coo
он
first isocitrate produced.
ÇoO
CH2
HÇ
-Co
HO-CH
c). Indicate the labeling pattern and distribution in oxaloacetate at the end of this
turn of the TCA cycle.:
čoo
Coo
CH2
d). What turn of the TCA cycle would label start to be lost as CO; (1 turn has been completed) ?
e). Which carbon in pyruvate would have been labeled to give you the labeling pattern in part c, if that pyruvate
went through PDH and the TCA cycle, instead of pyruvate carboxylase.
H3C
-co
f). How is the label in part c physically distributed on actual oxaloacetate molecules?

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