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1. What symptoms does Mr. Thompson have? 2. How do high levels of alkaline phosphatase indicate a bone abnormality? 3. What bones are often affected by Paget's disease? (Give at least 4) 4. What are the functions of osteoblasts and osteoclasts in the formation of bone? 5. The incidence rate of Paget's disease is highest in the elderly population and seems to be less prevalent in younger populations. Does this indicate a genetic or environmental cause? Explain. 6. Some individuals are unable to tolerate bisphosphonates well. Doctors sometimes prescribe a natural hormone that has similar properties. What do you suppose it is? (Hint: It is normally secreted by the thyroid gland.)

1. What symptoms does Mr. Thompson have? 2. How do high levels of alkaline phosphatase indicate a bone abnormality? 3. What bones are often affected by Paget's disease? (Give at least 4) 4. What are the functions of osteoblasts and osteoclasts in the formation of bone? 5. The incidence rate of Paget's disease is highest in the elderly population and seems to be less prevalent in younger populations. Does this indicate a genetic or environmental cause? Explain. 6. Some individuals are unable to tolerate bisphosphonates well. Doctors sometimes prescribe a natural hormone that has similar properties. What do you suppose it is? (Hint: It is normally secreted by the thyroid gland.)

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Answer the following questions CORRECTLY based on the reading. Thank you.
Case Study #4: Bone Breakdown Guided Case Study Your elderly neighbor. Fletcher Thompson, has been complaining of pain in his right leg for the past few months. You finally convince him to see a doctor, who recommends an X-ray. Upon looking at the X-rays, the doctor also orders a blood test. The results show high levels of alkaline phosphatase, an enzyme that aids in the mineralization of new tissue. The doctor diagnoses Mr. Thompson with osteitis deformans, more commonly known as Paget's disease of the bone. Paget's disease is common in the middle-aged population and is often asymptomatic. It causes the body to regenerate bone more often and faster than normal, resulting in bones that have a disorganized structure and reduced strength. This can lead to bone pain, deformities, and fractures. The affected bones are usually localized, but are most often in the axial skeleton and the long bones of the legs. Individuals with Paget's disease have overactive osteoblasts (bone- building cells) and osteoclasts (bone-killing cells), causing a process called dysregulation, which eventually distorts the normal skeletal structure. The cause of Paget's disease is still unknown, but there are hypotheses that it could have a genetic component and environmental causes. Although there is no cure for Paget's disease, there are treatments that can alter the bone regeneration process. Bisphosphonates (also commonly prescribed for osteoporosis) reduce osteoclast activity. Name: 1. What symptoms does Mr. Thompson have? 2. How do high levels of alkaline phosphatase indicate a bone abnormality? 3. What bones are often affected by Paget's disease? (Give at least 4) 4. What are the functions of osteoblasts and osteoclasts in the formation of bone? 5. The incidence rate of Paget's disease is highest in the elderly population and seems to be less prevalent in younger populations. Does this indicate a genetic or environmental cause? Explain. 6. Some individuals are unable to tolerate bisphosphonates well. Doctors sometimes prescribe a natural hormone that has similar properties. What do you suppose it is? (Hint: It is normally secreted by the thyroid gland.)
Transcribed Image Text:Case Study #4: Bone Breakdown Guided Case Study Your elderly neighbor. Fletcher Thompson, has been complaining of pain in his right leg for the past few months. You finally convince him to see a doctor, who recommends an X-ray. Upon looking at the X-rays, the doctor also orders a blood test. The results show high levels of alkaline phosphatase, an enzyme that aids in the mineralization of new tissue. The doctor diagnoses Mr. Thompson with osteitis deformans, more commonly known as Paget's disease of the bone. Paget's disease is common in the middle-aged population and is often asymptomatic. It causes the body to regenerate bone more often and faster than normal, resulting in bones that have a disorganized structure and reduced strength. This can lead to bone pain, deformities, and fractures. The affected bones are usually localized, but are most often in the axial skeleton and the long bones of the legs. Individuals with Paget's disease have overactive osteoblasts (bone- building cells) and osteoclasts (bone-killing cells), causing a process called dysregulation, which eventually distorts the normal skeletal structure. The cause of Paget's disease is still unknown, but there are hypotheses that it could have a genetic component and environmental causes. Although there is no cure for Paget's disease, there are treatments that can alter the bone regeneration process. Bisphosphonates (also commonly prescribed for osteoporosis) reduce osteoclast activity. Name: 1. What symptoms does Mr. Thompson have? 2. How do high levels of alkaline phosphatase indicate a bone abnormality? 3. What bones are often affected by Paget's disease? (Give at least 4) 4. What are the functions of osteoblasts and osteoclasts in the formation of bone? 5. The incidence rate of Paget's disease is highest in the elderly population and seems to be less prevalent in younger populations. Does this indicate a genetic or environmental cause? Explain. 6. Some individuals are unable to tolerate bisphosphonates well. Doctors sometimes prescribe a natural hormone that has similar properties. What do you suppose it is? (Hint: It is normally secreted by the thyroid gland.)
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