1. On October 22, 2020, the FDA approved Veklury (remdesivir structure shown below) for use in adults and pediatric patients for the treatment of COVID-19 requiring hospitalization. A) Calculate the Kier-Hall electronegativity index (x) of atoms a-c. H₂C H₂C CH3 N P d (CN) НО CEN OH NH₂ a (N) b (P) c (0) = 11 11 11 2245 IV C VNP C) Calculate the Kier-Hall electronegativity index (x) for functional group d. Show your calculations. VI VII F CI Br B) Using the information from A (above), denote the most polar bond in remdesivir by drawing its molecular dipole (use correct convention). 1
Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
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