1. LDA, THF 2. add slowly a) 3. Н.О 1. NaOCH¿CH3 b) 2 2. H,0* 1. LDA, THF 2. add slowly с) `OCH3 `OCH3 3. H3O*

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Chapter1: Chemical Foundations
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Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Give the major organic product of the following reaction sequences (a-e).

 

### Organic Chemistry Reaction Mechanisms

This educational resource provides a series of reaction mechanisms commonly encountered in organic chemistry, illustrating the stepwise transformation of various starting materials into their respective products using specified reagents and conditions.

#### Reaction a)
- **Starting Material**: A benzaldehyde with a ketone group.
- **Reagents and Conditions**:
  1. LDA (Lithium diisopropylamide), THF (Tetrahydrofuran)
  2. Slow addition of a propanone
  3. Hydrolysis with water (\(H_2O\))

#### Reaction b)
- **Starting Material**: 2-Pentanone with a methyl group.
- **Reagents and Conditions**:
  1. Sodium methoxide (\(NaOCH_2CH_3\))
  2. Acidic workup with \(H_3O^+\)

#### Reaction c)
- **Starting Material**: Ethyl acetate.
- **Reagents and Conditions**:
  1. LDA, THF
  2. Slow addition of ethyl acetate
  3. \(H_3O^+\) for acidic workup

#### Reaction d)
- **Starting Material**: 1,6-Hexanedione
- **Reagents and Conditions**:
  1. Aqueous sodium hydroxide (\(NaOH(aq)\))
  2. Heating with \(H_3O^+\)

#### Reaction e)
- **Starting Material**: Methyl acetate.
- **Reagents and Conditions**:
  1. Sodium methoxide in methanol (\(NaOCH_3, CH_3OH\))
  2. Addition of 1-bromopropane (\(CH_3CH_2CH_2Br\))
  3. Workup with \(H_3O^+\) and heat

**Note**: The molecules and specific transformation steps illustrated are representative of key organic synthetic techniques, such as enolate chemistry, aldol reactions, and Claisen condensations. They emphasize the use of strong bases, nucleophilic additions, and acid-catalyzed hydrolysis steps.
Transcribed Image Text:### Organic Chemistry Reaction Mechanisms This educational resource provides a series of reaction mechanisms commonly encountered in organic chemistry, illustrating the stepwise transformation of various starting materials into their respective products using specified reagents and conditions. #### Reaction a) - **Starting Material**: A benzaldehyde with a ketone group. - **Reagents and Conditions**: 1. LDA (Lithium diisopropylamide), THF (Tetrahydrofuran) 2. Slow addition of a propanone 3. Hydrolysis with water (\(H_2O\)) #### Reaction b) - **Starting Material**: 2-Pentanone with a methyl group. - **Reagents and Conditions**: 1. Sodium methoxide (\(NaOCH_2CH_3\)) 2. Acidic workup with \(H_3O^+\) #### Reaction c) - **Starting Material**: Ethyl acetate. - **Reagents and Conditions**: 1. LDA, THF 2. Slow addition of ethyl acetate 3. \(H_3O^+\) for acidic workup #### Reaction d) - **Starting Material**: 1,6-Hexanedione - **Reagents and Conditions**: 1. Aqueous sodium hydroxide (\(NaOH(aq)\)) 2. Heating with \(H_3O^+\) #### Reaction e) - **Starting Material**: Methyl acetate. - **Reagents and Conditions**: 1. Sodium methoxide in methanol (\(NaOCH_3, CH_3OH\)) 2. Addition of 1-bromopropane (\(CH_3CH_2CH_2Br\)) 3. Workup with \(H_3O^+\) and heat **Note**: The molecules and specific transformation steps illustrated are representative of key organic synthetic techniques, such as enolate chemistry, aldol reactions, and Claisen condensations. They emphasize the use of strong bases, nucleophilic additions, and acid-catalyzed hydrolysis steps.
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