1. For each of the following statements, indicate whether they are true of false. ⚫ a good way of thinking about meta directing groups is that they disfavour reaction at the ortho and para positions rather than promoting reaction at the meta position. ⚫ all activating (electron donating) groups are ortho/para directors and all deactivating (electron withdrawing) groups are meta directors. ⚫ diazotization of an amino group is very useful because the diazo group can be replaced with a number of other substituents. • benzene rings bearing meta directing groups cannot undergo Friedel-Crafts reactions. ⚫ when more than one substituent is present on a benzene ring, the directing effects of all substituents should be considered. ⚫ when substituents have conflicting directing effects, mixtures of products can form, but a strongly activating group can outweigh the effects of groups below it on the electron donation/withdrawal scale. ⚫ in a nucleophilic aromatic substitution reaction, the incoming nucleophile must be a weaker base than the halide ion that is being replaced.

Organic Chemistry: A Guided Inquiry
2nd Edition
ISBN:9780618974122
Author:Andrei Straumanis
Publisher:Andrei Straumanis
Chapter27: Amines
Section: Chapter Questions
Problem 5E
Question
1. For each of the following statements, indicate whether they are true of false.
⚫ a good way of thinking about meta directing groups is that they disfavour reaction at the ortho
and para positions rather than promoting reaction at the meta position.
⚫ all activating (electron donating) groups are ortho/para directors and all deactivating (electron
withdrawing) groups are meta directors.
⚫ diazotization of an amino group is very useful because the diazo group can be replaced with a
number of other substituents.
• benzene rings bearing meta directing groups cannot undergo Friedel-Crafts reactions.
⚫ when more than one substituent is present on a benzene ring, the directing effects of all
substituents should be considered.
⚫ when substituents have conflicting directing effects, mixtures of products can form, but a
strongly activating group can outweigh the effects of groups below it on the electron
donation/withdrawal scale.
⚫ in a nucleophilic aromatic substitution reaction, the incoming nucleophile must be a weaker
base than the halide ion that is being replaced.
Transcribed Image Text:1. For each of the following statements, indicate whether they are true of false. ⚫ a good way of thinking about meta directing groups is that they disfavour reaction at the ortho and para positions rather than promoting reaction at the meta position. ⚫ all activating (electron donating) groups are ortho/para directors and all deactivating (electron withdrawing) groups are meta directors. ⚫ diazotization of an amino group is very useful because the diazo group can be replaced with a number of other substituents. • benzene rings bearing meta directing groups cannot undergo Friedel-Crafts reactions. ⚫ when more than one substituent is present on a benzene ring, the directing effects of all substituents should be considered. ⚫ when substituents have conflicting directing effects, mixtures of products can form, but a strongly activating group can outweigh the effects of groups below it on the electron donation/withdrawal scale. ⚫ in a nucleophilic aromatic substitution reaction, the incoming nucleophile must be a weaker base than the halide ion that is being replaced.
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