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1. Chris and Emma are phenotypically normal but carriers for SCA (gene A). a. What are their genotypes? b. With respect to gene A, what are the possible genotypes of the gametes that they can produce. Emma: Chris: ||

1. Chris and Emma are phenotypically normal but carriers for SCA (gene A). a. What are their genotypes? b. With respect to gene A, what are the possible genotypes of the gametes that they can produce. Emma: Chris: ||

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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The gene involved in the disease **Sickle Cell Anemia (SCA)** is on human chromosome 11. Allele "A" is the normal form of the gene and codes for a part of the protein complex called hemoglobin. Hemoglobin is required for your blood cells to carry oxygen. Allele "a" is an abnormal form of the gene. The hemoglobin protein made from the "a" allele is defective. Red blood cells containing the defective protein are very fragile. This disease is recessive—meaning that you have to inherit two copies of the recessive allele in order to be affected with the disease SCA. The gene involved in the disease **Cystic Fibrosis (CF)** is on human chromosome 7. Allele "B" is the normal form of the gene and codes for a channel protein that allows chloride to pass through a cell. Allele "b" is the abnormal form of the gene. The channel protein made from the "b" allele is defective and doesn’t insert into the cell’s plasma membrane, resulting in an inability of sodium and chloride to cross the membrane. CF is also recessive therefore only people with two defective copies of the gene (“bb”) are affected with the disease. 1. Chris and Emma are phenotypically normal but carriers for SCA (gene A). a. What are their genotypes? b. With respect to gene A, what are the possible genotypes of the gametes that they can produce. - Chris: ____ ____ - Emma: ____ ____ In front of each gamete genotype, write the probability of producing that gamete. c. What is the probability that Chris and Emma will have a child affected with SCA? (affected = has the disease “aa” = homozygous recessive) d. Write the cross and the Punnett square that demonstrates this. ``` ___ ___ x ___ ___ ``` e. The phenotypic ratio is ____ normal : ____ affected. The genotypic ratio is ____ AA : ____ Aa : ____ aa. 2. Chris and Emma are also carriers for CF (gene B is on chromosome 7). Both are genotype Bb. a. What is the probability that they will have a child affected with CF? (affected = has the disease “bb” = homozygous recessive) b
Transcribed Image Text:The gene involved in the disease **Sickle Cell Anemia (SCA)** is on human chromosome 11. Allele "A" is the normal form of the gene and codes for a part of the protein complex called hemoglobin. Hemoglobin is required for your blood cells to carry oxygen. Allele "a" is an abnormal form of the gene. The hemoglobin protein made from the "a" allele is defective. Red blood cells containing the defective protein are very fragile. This disease is recessive—meaning that you have to inherit two copies of the recessive allele in order to be affected with the disease SCA. The gene involved in the disease **Cystic Fibrosis (CF)** is on human chromosome 7. Allele "B" is the normal form of the gene and codes for a channel protein that allows chloride to pass through a cell. Allele "b" is the abnormal form of the gene. The channel protein made from the "b" allele is defective and doesn’t insert into the cell’s plasma membrane, resulting in an inability of sodium and chloride to cross the membrane. CF is also recessive therefore only people with two defective copies of the gene (“bb”) are affected with the disease. 1. Chris and Emma are phenotypically normal but carriers for SCA (gene A). a. What are their genotypes? b. With respect to gene A, what are the possible genotypes of the gametes that they can produce. - Chris: ____ ____ - Emma: ____ ____ In front of each gamete genotype, write the probability of producing that gamete. c. What is the probability that Chris and Emma will have a child affected with SCA? (affected = has the disease “aa” = homozygous recessive) d. Write the cross and the Punnett square that demonstrates this. ``` ___ ___ x ___ ___ ``` e. The phenotypic ratio is ____ normal : ____ affected. The genotypic ratio is ____ AA : ____ Aa : ____ aa. 2. Chris and Emma are also carriers for CF (gene B is on chromosome 7). Both are genotype Bb. a. What is the probability that they will have a child affected with CF? (affected = has the disease “bb” = homozygous recessive) b
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