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1. a) The Williamson synthesis is a very important method to prepare asymmetric ethers. In the first step of this reaction the alcohol is converted to an alkoxide as shown. Why is this necessary? ROH+ NaHRONa+ + H₂ b) The Williamson synthesis works best if the alkyl halide is primary. Why is this true? c) Why is NaH rather than NaOH used in this reaction?

1. a) The Williamson synthesis is a very important method to prepare asymmetric ethers. In the first step of this reaction the alcohol is converted to an alkoxide as shown. Why is this necessary? ROH+ NaHRONa+ + H₂ b) The Williamson synthesis works best if the alkyl halide is primary. Why is this true? c) Why is NaH rather than NaOH used in this reaction?

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
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1. a) The Williamson synthesis is a very important method to prepare asymmetric ethers. In the first step of this reaction the alcohol is converted to an alkoxide as shown. Why is this necessary? b) The Williamson synthesis works best if the alkyl halide is primary. Why is this true? ROH+ NaHRONa+ + H₂ c) Why is NaH rather than NaOH used in this reaction? Fill in the missing parts of the Williamson reaction shown below. OH + 2Na Br- + H₂ CH3
Transcribed Image Text:1. a) The Williamson synthesis is a very important method to prepare asymmetric ethers. In the first step of this reaction the alcohol is converted to an alkoxide as shown. Why is this necessary? b) The Williamson synthesis works best if the alkyl halide is primary. Why is this true? ROH+ NaHRONa+ + H₂ c) Why is NaH rather than NaOH used in this reaction? Fill in the missing parts of the Williamson reaction shown below. OH + 2Na Br- + H₂ CH3
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