1. A protein chromatography column that processes 15 kg of protein in 60 h, is cycled every 6 h, can be loaded with 10 grams of protein per liter of column volume, has a maximum flow rate of 50 liters/ min at a pressure of 4 bar, and is packed with an incompressible resin having a particle diameter of 90 μum and void fraction of 0.35. The viscosity can be assumed to be that of water. i. What are the dimensions required for the column? ii. If the flow rate is 1 column volume per minute and the pressure rating is still 4 bar, what column dimensions are required? Is the resolution equivalent to that for Part (i)? 111. If the pressure rating for the column were raised to 12 bar, should the column dimensions change? Is so, what should the dimensions be? Do they make sense? iv. What is the best way to increase the productivity of the column packing?

1. A protein chromatography column that processes 15 kg of protein in 60 h, is cycled every 6 h, can be loaded with 10 grams of protein per liter of column volume, has a maximum flow rate of 50 liters/ min at a pressure of 4 bar, and is packed with an incompressible resin having a particle diameter of 90 μum and void fraction of 0.35. The viscosity can be assumed to be that of water. i. What are the dimensions required for the column? ii. If the flow rate is 1 column volume per minute and the pressure rating is still 4 bar, what column dimensions are required? Is the resolution equivalent to that for Part (i)? 111. If the pressure rating for the column were raised to 12 bar, should the column dimensions change? Is so, what should the dimensions be? Do they make sense? iv. What is the best way to increase the productivity of the column packing?

Cornerstones of Cost Management (Cornerstones Series)

4th Edition

ISBN:9781305970663

Author:Don R. Hansen, Maryanne M. Mowen

Publisher:Don R. Hansen, Maryanne M. Mowen

Chapter20: Inventory Management: Economic Order Quantity, Jit, And The Theory Of Constraints

Section: Chapter Questions

Problem 14E: Hales Company produces a product that requires two processes. In the first process, a subassembly is...

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