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1) Proteins undergo a process called thermal denaturation. This is a process where the protein unfolds (denaturates) as the temperature is increased. (This has important practical consequences for protein based pharmaceuticals). Later this semester we will see that proteins can also denaturate if they are cooled too much. For now we will consider heat denaturation: Protein (folded) → Protein(unfolded) . For a certain protein Adenaturation H is 418.0 k.J mol¬! and Adenaturation S = 1.30 k.J K-1 mol-1. Assume that these values of Adenaturation H and Adenaturation S are independent of temperature (this is actually a bad assumption in real life). A) Calculate AdenaturationG at 310 K. Do you expect the thermal denaturation of the protein to be spontaneous? B) Does the entropy change favor the folded state or the unfolded state at 310 K? C) At what temperature is AdenaturationG zero? We usually call this temperature the “melting temperature" of the protein.

1) Proteins undergo a process called thermal denaturation. This is a process where the protein unfolds (denaturates) as the temperature is increased. (This has important practical consequences for protein based pharmaceuticals). Later this semester we will see that proteins can also denaturate if they are cooled too much. For now we will consider heat denaturation: Protein (folded) → Protein(unfolded) . For a certain protein Adenaturation H is 418.0 k.J mol¬! and Adenaturation S = 1.30 k.J K-1 mol-1. Assume that these values of Adenaturation H and Adenaturation S are independent of temperature (this is actually a bad assumption in real life). A) Calculate AdenaturationG at 310 K. Do you expect the thermal denaturation of the protein to be spontaneous? B) Does the entropy change favor the folded state or the unfolded state at 310 K? C) At what temperature is AdenaturationG zero? We usually call this temperature the “melting temperature" of the protein.

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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NOT a graded assignment. From my understanding it is just (Delta G) = (Delta H) - (T)(Delta S) for part A. I am confused about the "unfolding" part and the last part.

1) Proteins undergo a process called thermal denaturation. This is a process where the protein unfolds (denaturates) as the temperature is increased. (This has important practical consequences for protein based pharmaceuticals). Later this semester we will see that proteins can also denaturate if they are cooled too much. For now we will consider heat denaturation: Protein (folded) → Protein(unfolded) . For a certain protein Adenaturation H is 418.0 kJ mol-' and Adenaturation S = 1.30kJ K-1 mol-1. Assume that these values of Adenaturation H and Adenaturation S are independent of temperature (this is actually a bad assumption in real life). A) Calculate AdenaturationG at 310 K. Do you expect the thermal denaturation of the protein to be spontaneous? B) Does the entropy change favor the folded state or the unfolded state at 310 K? C) At what temperature is AdenaturationG zero? We usually call this temperature the "melting temperature" of the protein.
Transcribed Image Text:1) Proteins undergo a process called thermal denaturation. This is a process where the protein unfolds (denaturates) as the temperature is increased. (This has important practical consequences for protein based pharmaceuticals). Later this semester we will see that proteins can also denaturate if they are cooled too much. For now we will consider heat denaturation: Protein (folded) → Protein(unfolded) . For a certain protein Adenaturation H is 418.0 kJ mol-' and Adenaturation S = 1.30kJ K-1 mol-1. Assume that these values of Adenaturation H and Adenaturation S are independent of temperature (this is actually a bad assumption in real life). A) Calculate AdenaturationG at 310 K. Do you expect the thermal denaturation of the protein to be spontaneous? B) Does the entropy change favor the folded state or the unfolded state at 310 K? C) At what temperature is AdenaturationG zero? We usually call this temperature the "melting temperature" of the protein.
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