1) Draw the mechanism/intermediates and predict the products for the following Claisen Condensation (note: I won't draw two copies of the reactant on homework or evaluations): i) NaOCH,CH,, CH,CH,OH ii) H,0* 2) Draw the intermediates and predict the products for the following Acetoacetic Ester Synthesis: i) Nao ii) Br iii) acid and heat 3) Draw the intermediates and predict the products for the following Malonic Ester Synthesis: i) NaOEt ii) Br iii) acid and heat EtO OEt

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Products from Carbonyl-Containing Nucleophiles
1) Draw the mechanism/intermediates and predict the products for the following Claisen
Condensation (note: I won't draw two copies of the reactant on homework or evaluations):
i) NaOCH,CH,,
CH,CH,OH
ii) H,O*
the intermediates and
the products for the follov
Acetoacetic Ester
i) Nao
ii)
Br
iii) acid and heat
3) Draw the intermediates and predict the products for the following Malonic Ester Synthesis:
i) NaOEt
ii)
Br
EtO
OEt
ii) acid and heat
4) For each of the above reactions, circle the parts of the reactants that are removed/lost during
the reactions.
Transcribed Image Text:Products from Carbonyl-Containing Nucleophiles 1) Draw the mechanism/intermediates and predict the products for the following Claisen Condensation (note: I won't draw two copies of the reactant on homework or evaluations): i) NaOCH,CH,, CH,CH,OH ii) H,O* the intermediates and the products for the follov Acetoacetic Ester i) Nao ii) Br iii) acid and heat 3) Draw the intermediates and predict the products for the following Malonic Ester Synthesis: i) NaOEt ii) Br EtO OEt ii) acid and heat 4) For each of the above reactions, circle the parts of the reactants that are removed/lost during the reactions.
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