0000 0 Question 1 Herbicides were used extensively during the Vietnam War to defoliate dense jungle areas. The concentration of certain herbicide by-products in the soil remains high today. Reactions that introduce a halogen substituent on a benzene ring are widely used, and many halogenated aromatic compounds with a range of biological activity have been synthesized. out on Generic name bupropion Trade names Wellbutrin, Zyban antidepressant, also used to reduce nicotine cravings chlorpheniramine antihistamine 2,4-D 2,4-dichlorophenoxy- acetic acid herbicide OH CI CI 2,4,5-T 2,4,5-trichlorophenoxy- acetic acid herbicide the active components in Agent Orange, a defoliant used in the Vietnam War Credit: Smith, Organic Chemistry p.729 Consider the examples of biologically active aryl chlorides. Select All that apply The antidepressant Wellbutrin has an ortho substitution pattern The antidepressant Wellbutrin has an meta substitution pattern The antidepressant Wellbutrin has an para substitution pattern The antidepressant Wellbutrin has an Ortho and meta substitution pattern OH

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Q: C A Free Energy (kcal/mol) 20

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Organomagnesium compounds

The interaction of alkyl halide with Mg metal in a suitable ether solvent is the common method for the synthesis of the Grignard reagent.

Hydrolysis Grignard Reactions and Reduction

Organomagnesium halides are Grignard reagents. Francois Auguste Victor Grignard, a French chemist who received the Nobel Prize in Chemistry in 1912, created these highly useful reagents.