APRN 707 The Immortal Life of Henrietta Lacks

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1 The Immortal Life of Henrietta Lacks: An Ethical Paper Francis Marion University APRN 707: Clinical Decision-Making & Ethics Dr. Hucks July 25, 2021
2 Abstract This paper will discuss the book by Rebecca Skloot, “The Immortal Life of Henrietta Lacks.” The paper will outline my synopsis and impression of the book. It will also give detail to one ethical dilemma that was portrayed in the book in relation to the ANA’s Code of Ethics. The use of narrative medicine will also be discussed, both the good and bad. This paper will also dive into the different aspects and parallels between the disease and treatment that Henrietta Lacks endured to COVID-19. Lastly, this paper will describe how my practice has been impacted and influenced from this book and the information learned from it. Keywords: Henrietta Lacks, ethical dilemmas, COVID-19, narrative medicine
3 The Immortal Life of Henrietta Lacks: An Ethical Paper The story of Henrietta Lacks portrays racism, terrible and painful life experiences of the family that was left behind, and the violation of scientific ethics. Rebecca Skloot wrote the book “The Immortal Life of Henrietta Lacks” who was the mother of five children and was diagnosed with cervical cancer and her cells were harvested without her knowledge or consent (Skloot, 2010). In the 1950’s, medical professionals were not mandated to get consent from their patients (Skloot, 2010). Not only was Henrietta unaware of her cells being taken but so was her family. For years, they were unaware of the impact that her cells had on the medical field (Skloot, 2010). Henrietta endured the most horrendous life events that began at the tender age of four. She lost her mother and her father decided to uproot their lives and relocate the family. She fell pregnant at fourteen by her cousin, Day Lacks (Skloot, 2010). Life never really favored Henrietta and it is hard for me not to think that her life would have been very different had her father not relocated them. Henrietta’s children were Lawrence, Elsie, Deborah, Sonny, and Joe (Skloot, 2010). Life also never favored her children, as each of them also faced many challenges and hardships. Deborah was also a teen mother and was married to her boyfriend (Skloot, 2010). This was an unhappy union and resulted in divorce soon after. Elsie had mental handicaps that made everyday life hard (Skloot, 2010). This handicap could depict the negative outcomes that results from inbreeding. Lawrence did not finish school and was sent to Vietnam (Skloot, 2010). Sonny was in the Airforce and ended up on drugs (Skloot, 2010). Her son Joe killed a man and converted his religion to Islam (Skloot, 2010). There were several social, environmental, and behavioral aspects present in the book that potentially led to the mishap and suffering endured by Henrietta prior to her death and that of her
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4 family after her passing. Henrietta Lacks was African American, and it is thought that the decision to harvest and use her cells for scientific purposes was directly linked to her race. The book took place during the 1950’s and African Americans were believed to be lesser than others during this time. The cells that were harvested from Henrietta without consent are known as HeLa cells (Skloot, 2010). Although the act of taking them without her knowledge or consent is ethically wrong, the study of the cells has profoundly broadened cancer research and treatment (Skloot, 2010). There is now a better understanding of cancers and the possibly implications it may have on patients (Skloot, 2010). There were several different themes that were evident in this book. The first is that of dehumanization. Dehumanization is when the qualities of individuals are stripped away (Smith, 2012). The death of Henrietta was not concerning to the medical professionals; however, they were deeply involved with the research that was arising from her cells. The next theme throughout the book is immortality. Her cells have proven to provide groundbreaking knowledge in the field of cancer research as they were the first human cells that were able to grow in the laboratory (Skloot, 2010). Even after the cells were removed and separated from her body, they lived (Skloot, 2010). The idea of racism that was present in medicine was shown through the reading. The harvesting of cells without the consent of an African American women led to the distrust of doctors and medical professionals by African Americans (Skloot, 2010). Racism was also portrayed as Henrietta sought treatment at Johns Hopkins since it was the only hospital that would treat African Americans. The hospital would treat African Americans but remained segregated at this time (Skloot, 2010). The hospital provided care in their public ward for those
5 of poverty, Caucasian or African American (Skloot, 2010). The belief that since her care was being received at no cost, there was no issue with taking the cells for free as well. My Synopsis and Impression I feel as if the book profoundly represents and brings to light a common factor that is still very much present today. That is how most individuals tend to take advantage of another’s misfortune to benefit in some aspect. The doctors at Johns Hopkins did not take the most appropriate approach to treatment for Henrietta Lacks condition. Instead, they harvested cells without permission that would potentially benefit their careers. Skloot (2010) depicts the events that occurred as a “necessary evil” especially for the field of modern medicine. Medical ethics have since evolved and medical professionals are required to receive consent prior to proceeding with any procedures or treatments (Skloot, 2010). There was a lack of education and guidance available to Henrietta and I believe had the resources been provided, the decisions she made regarding her healthcare would have been much different. Ethical Issues Henrietta Lacks story has raised many ethical questions that remain unanswered to this day. One being should individuals have the right to control what is done with their specimens once they leave their bodies? There are millions of samples that have been collected during procedures such as fetal genetic-disease screenings and circumcisions that cannot be linked to an individual. The samples are used for medical research and pave the way for medical advancements, but does that make it right? I think it is safe to say that individuals want research into diseases, treatments, and cures to continue. However, I also believe that individuals want to be aware when it is their specimens being collected and used.
6 When the medical community stands to benefit and profit from the use of these specimens, should a portion of that profit and acknowledgement be shared with the beholder? Skloot (2010) demonstrates and displays the countless relief that has been gained to patients from the harvest of the HeLa cells. However, the Lacks family has had to endure not only losing their mother, but not knowing about the use of her cells which led to confusion, pain, and embarrassment (Skloot, 2010). You must ask yourself, is the greater good enough compensation for all those individuals face afterwards (Skloot, 2010)? Grace (2018) states that when the subject of research involves human subjects, there is a temptation and tendency of those conducting the research to lose sight of the goal. The goal of human subject research is the promotion of good to humans (Grace, 2018). Most healthcare providers may feel like they understand the meaning of human subject research, however, the constitutions of human subject research can be difficult as they are not always clear cut (Grace, 2018). The Code of Federal Regulations (C.F.R.) defines research as a “systemic investigation, including research development, testing, and evalution, designed to develop or contribute to generalizable knowledge” (Grace, 2018, pg. 175). They also define human subjects as “a living induvial about whom an investigator (whether professional or student) conducting research obtains (1) Data through intervention or interaction with the individual, or (2) Identifiable private information (Grace, 2018, pg. 175). Using human subjects for research dates to ancient Roman times (Grace, 2018). However, we are now aware of what is know as human subject abuses (Grace, 2018). There are several indicative attitudes that coincide with these abuses such as: researchers desire to further the social good regardless if it is risky for the participants, the human subjects are not a significant moral concern and the want to gain information by any means, the belief that certain
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7 classes of individuals like slaves, minorities, and lower classes are not as worthy of concerns as others, some individuals are disposable, and the want and pressure to complete the ambition whether it is personal or professional (Grace, 2018). Research in different fields have led to an increased understanding on the influence of bias, prejudice, and self-interest of action has had on research that is derived from human subjects (Grace, 2018). There has been many advancements and developments in the regulations and policies related to human subject research regulations (Grace, 2018). The Nuremberg Code and The Declaration of Helsinki are two that were discussed in Grace (2018). The Nuremberg Code was established as an attempt to protect the rights of humans and states that “the voluntary consent of the human subject is absolutely essential” (Grace, 2018, pg. 180). The Declaration of Helsinki introduced the idea of proxy consent (Grace, 2018). This was permitting another individual to give permission for an individual without decision-making capacity to participate in research studies (Grace, 2018). Neither of these developments were pertinent or helpful for Henrietta Lacks. Her cells were still harvested unbeknownst to her or her family and used for revolutionary scientific findings. The ethical principle of autonomy, or respect for persons, was completely disregarding in the case of Henrietta Lacks. There was a lack of respect shown for her as an African American woman with only a sixth-grade education (Skloot, 2010). The ethical principle of altruism also comes to mind when regarding Henrietta Lacks. Altruism is the motivation that is not primarily that of self-serving but more for the interests of others (Grace, 2018). Henrietta was not given the opportunity to independently help aid in the research and benefits to others that came from her cells. Would she have consented had she been given the chance?
8 There are difficulties in protecting human research subjects’ rights that have not been resolved and are still present today (Grace, 2018). However, due to cases in the pass like that of Henrietta Lacks, the research endeavors involving human subjects have been greatly improved (Grace, 2018). Society recognizes and appreciates the need for ongoing research that contain human subjects and strives to improve the process have been made and are still being made (Grace, 2018). Narrative Medicine The art of narratives has always held a critical role in that of medicine (Kalitzkus & Matthiessen, 2009). However, narrative medicine has changed from the provider’s narrative to the narrative of the patient (Kalitzkus & Matthiessen, 2009). Narrative medicine is a growing field in the healthcare arena and is one that strives to provide a more satisfying medical experience (Wong, 2020). The practice of narrative medicine is one that encourages the patients to their stories regarding their health (Wong, 2020). The belief is that providers can more thoroughly and accurately provide care and treatment to the patient regarding the condition(s) (Wong, 2020). Providers that practice by means of narrative medicine believe that a patient’s emotions and life experiences have likely influenced their health and they desire to get an understanding that is deep from the patient’s story (Wong, 2020). When the patient shares their story, the provider feels they can receive a more complete picture of illness and condition and just how it has impacted the patient’s everyday life (Wong, 2020). The use of narrative medicine is also believed to offer a more insightful treatment approach and different self-care strategies that are more conducive to the patient (Wong, 2020).
9 Dr. Rita Charon stated that narrative medicine is the means to bridge any divides that may be separating the provider and the patient and is a more holistic approach to treatment (Wong, 2020). Narrative medicine primarily looks past the symptoms and treatment options and allows the provider to consider the patient’s needs, beliefs, and values (Wong, 2020). The patient is viewed as a whole and as unique to any other patient (Wong, 2020). One benefit to using narrative medicine is that empathy is instilled in the provider which improves the quality of care that is received by the patients (Wong, 2020). Studies have shown that more positive patient outcomes are linked to higher levels of provider empathy (Wong, 2020). The field of narrative medicine requires significant technical and attitude changes to occur, and those changes do not always happen quickly (Kalitzkus & Matthiessen, 2009). Another downfall to narrative medicine is that several patients and providers feel intimidated (Wong, 2020). Also, the fact that the field of narrative medicine is still-emerging, and many providers and patients may be unfamiliar with all the principles that this practice may entail (Wong, 2020). The biggest challenge of narrative based practices is the art of knowing when to stop (Kalitzkus & Matthiessen, 2009). Providers in the narrative medicine field tend to get carried away by the idea of the narratives but disease, disability, deprivation, and death are not stories but are facts (Kalitzkus & Matthiessen, 2009). I believe that the use of narrative medicine is beneficial regarding the story of Henrietta Lacks for many different reasons. However, I believe that the most important is that it provides some means of closure to her family. It is also important because in healthcare practices today, medical research heavily relies on biological samples like that of the HeLa cells from Henrietta. The family now knows just how important her cells were to medical advancements and they have had the chance to ask questions that they have longed to have the answers to for quite some
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10 time (Skloot, 2010). They can now have a peace of mind that her cells have provided research that has ended many peoples suffering (Skloot, 2010). Although that is not a replacement for what was done to her, it is some sort of peach of mind for them. The HeLa cells were the first ‘immortal’ cell line that was ever capable of growing in the laboratory and is now used in laboratories all over the world for medical research purposes and advancements to diagnosis, treatment, and care plans (Skloot, 2010). Her family is finally able to see just how important Henrietta’s contribution was and she deserves be remembered by them and society as whole as a true medical hero. COVID-19 Parallels The coronavirus disease 2019 (COVID-19) is a pandemic that has ultimately place horrific demands and strains on the healthcare field and the healthcare providers worldwide (Chamsi-Pasha, Chamsi-Pasha, & Albar, 2020). There have been numerous ethical issues that are challenging and unprecedented across the globe (Chamsi-Pasha, Chamsi-Pasha, & Albar, 2020). There has been an abundance of patients that require critical care and in turn, creating a scarcity of critical care resources (Chamsi-Pasha, Chamsi-Pasha, & Albar, 2020). This also revealed the need for a formal standard of care for crisis’s (Chamsi-Pasha, Chamsi-Pasha, & Albar, 2020). There has been more difficult life and death decisions made during this pandemic that has resulted in severe moral distress to the providers (Chamsi-Pasha, Chamsi-Pasha, & Albar, 2020). There have also been other ethical dilemmas to arise such as conduction of clinical trials to potentially save lives and the increase of deaths related to domestic violence because of the quarantine requirements (Chamsi-Pasha, Chamsi-Pasha, & Albar, 2020). Ethical questions regarding the need for treatment prioritization, personal protective equipment availability, testing, and resuscitation decisions have all arose due to the pandemic
11 (Chamsi-Pasha, Chamsi-Pasha, & Albar, 2020). As the pandemic continues to progress, other ethical based challenges tend to arise such as the best means for dealing with vaccination research and how patients are prioritized in relation to receival of medical care and supplies (Chamsi-Pasha, Chamsi-Pasha, & Albar, 2020). One correlation between the COVID-19 disease and the story of Henrietta Lacks is that of vulnerability. Henrietta’s cells were harvested without her consent due to her being an uneducated, African American women from a lower class. Which is also the case for some aspects of treatment for COVID-19. Allocation of lifesaving resources that are in scarce supply makes the geriatric population, minorities, and those with disabilities more vulnerable to a lapse in treatment (Chamsi-Pasha, Chamsi-Pasha, & Albar, 2020). The teams that are responsible for triaging the patients should be adequately equipped to put in place the criteria for prioritization, that will minimize bias and avoid any negative outcomes or consequences (Chamsi-Pasha, Chamsi-Pasha, & Albar, 2020). Henrietta Lacks should have been afforded these rights to her care as well. There have been numerous critical decisions made when the whole truth was not disclosed or there were small fabrications made. The decision to withdraw life sustaining care can be difficult in general. However, when there are means of miscommunications, lack of communication, or fabrications to the information, the decision becomes even more of an ethical dilemma (Chamsi-Pasha, Chamsi-Pasha, & Albar, 2020). This was in a sense the same scenario that occurred with Henrietta. There was no communication regarding taking her cells from her or the intention of use for them. Her family was also kept in the dark for many years after her passing about the collection and use of her cells. There were also fabrications about the harvest in a means to cover up the story and events that transpired.
12 The relationship between medicine and ethics is one that is intimate and unequivocal (Chamsi-Pasha, Chamsi-Pasha, & Albar, 2020). The contribution of ethical perspectives is one that is invaluable, especially during a pandemic or cases such as Henrietta Lacks cell harvest (Chamsi-Pasha, Chamsi-Pasha, & Albar, 2020). For current providers to make the proper decisions and maintain the best standard and quality of care for their patients, it is crucial that the ethical challenges that emerge be identified and resolved (Chamsi-Pasha, Chamsi-Pasha, & Albar, 2020). The cells from Henrietta Lacks have been used to carry out research for some of the most profound medical breakthroughs we will see in our time and some before our time (Henrietta Lacks and her contribution…, 2020). Research regarding the first polio vaccine, in-vitro fertilization, cancer, and effects of SARS-CoV replication in the body has steamed from the cells received without consent from Henrietta Lacks. The research has provided input for development of a vaccine for the coronavirus 19 (Henrietta Lacks and her contribution…, 2020). COVID-19 has wreaked havoc on the minorities in America and the scientific field is being forced to acknowledge and confront the unequal treatment to blacks and other minorities historically and present times (Henrietta Lacks and her contribution…, 2020). Many of the cells that are utilized in the research of vaccine formulation is that of cells derived from elected abortions (Henrietta Lacks and her contribution…, 2020). However, there have been incentives from the Catholic leaders for COVID-19 vaccines that do not utilize fetal cells (Henrietta Lacks and her contribution…, 2020). The use of the HeLa cells proposed different questions and possibilities in the development of vaccinations for COVID-19 (Henrietta Lacks and her contribution…, 2020). The prospect of ‘restorative justice’ emerges as many of the contributions in the medical field from blacks over the years have been disregarded or not
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13 acknowledged (Henrietta Lacks and her contribution…, 2020). The hope to correct the historical wrongdoing of Henrietta Lacks and other minorities that have contributed to advancing the medical field lies in the vaccination commencing in full force (Henrietta Lacks and her contribution…, 2020). Impact and Influence on My Practice “The Immortal Life of Henrietta Lacks” was such an insightful read. I feel as if there was so much information that I learned and so much information that I long to learn more about. One major aspect I took from this was that of humanity. I intend to practice with the mindset of never allowing my desire for certain aspects cloud my recognition of the humanity of my patients. I also learned that I do not ever want to submit to others when the actions are wrong or may inflict pain upon my patients. I also never intend to be the authoritative figure that puts my coworkers in that position as well. I want the best interest of my patients and their loved ones to be the center of my care and the backbone of how I provide care. At the end of the day, healthcare providers went into this field to provide help and guidance to those that are in need. We should remember that and strive to always keep our patients and their goals and outcomes as the top priority. I know that this will not always be easy and that I will be faced with numerous ethical dilemmas and challenges. However, I hope that I will elicit the appropriate help and guidance and that the patient will always receive the best quality of care and empathy that I can provide them.
14 References Chamsi-Pasha, H., Chamsi-Pasha, M., & Albar, M. A. (2020). Ethical dilemmas in the era of COVID-19. Avicenna journal of medicine, 10 (3), 102-105. https://doi.org/10.4103/ajm.ajm_119_20 Grace, P. J. (2018). Nursing ethics and professional responsibility in advanced practice (3 rd ed.). Jones & Bartlett. Henrietta Lacks and her contribution to Covid-19 vaccine (2020). Hindustan times. https://www.hindustantimes.com/world-news/who-is-henrietta-lacks-and-what-s-her- connection-to-the-covid-19-vaccine/story-neC7CB4IUabGiFgJVbbp2L.html Kalitzkus, V. & Matthiessen, P. F. (2009). Narrative-based medicine: potential, pitfalls, and practice. The Permanente journal, 13 (1), 80-86. https://doi.org/10.7812/tpp/08-043 Skloot, R. (2010). The immortal life of Henrietta Lacks. Crown Publishers. Smith, M. (2012). Dehumanization in medicine. Counsel & Heal: Mental Health. https://www.counselheal.com/articles/1393/20120323/dehumanization-medicine.html Wong, C. (2020). How narrative medicine might benefit you. Verywell Health. https://www.verywellhealth.com/narrative-medicine-benefits-uses-and-tips- 4143186#:~:text=One%20of%20the%20core%20principles%20of%20narrative %20medicine,be%20associated%20with%20more%20positive%20outcomes%20in %20patients .
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