Bios256 week 4 Lab

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Chamberlain College of Nursing *

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Jan 9, 2024

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BIOS256 OL, Week 4 Lab Name: Heidinette Roman OL Lab 4: Renal Physiology: Find the mode of action of a diuretic drug Learning Objectives:  Understand the morphological relationships between the kidney tubules and the circulatory system  Analyze experimental data for calculating glomerular filtration rate  Set up and perform a perfusion of renal tubules, including the calculation of liquid absorption rates  Learn about the epithelial transport mechanism in the kidney tubules  Use experimental data to assess the mode of action of a diuretic drug Kidneys play a critical role in the filtration and reabsorption of essential substances that are required for the body. In this simulation, you will explore the anatomy of the kidney through 3D holograms and identify the physiological roles in maintaining homeostasis as well as the factors that influence urine regulation. In this simulation, you will use the kidney from a dissected rat to study the mode of action of a new diuretic drug and learn the reabsorption process in the renal tubules. You will learn how to calculate the glomerular filtration rate or GFR and learn the hormones that influence urine output. At the end of the simulation, you should be able to correlate the relationship between renal and circulatory systems in controlling blood pressure. Part 1: Complete Labster- Renal Physiology: Find the mode of action of a diuretic drug Part 2: Report and Reflection Purpose: Describe in your own words and in complete sentences, the purpose of this experiment. The primary objective of this experiment is to get a comprehensive understanding of the etiology and therapeutic interventions for hypertension. Observations: List 2 observations you have made in this simulation. Upon careful observation, it becomes evident that the nephron, a crucial anatomical unit responsible for renal filtration and urine formation, is found in both the cortical and medullary regions of the kidney. The glomerular capillaries exhibit a remarkable propensity for extruding substantial quantities of solutes.

BIOS256 OL, Week 4 Lab Name: Heidinette Roman Answer all the questions below: 1. In the simulation, why was the ascending limb of the nephron selected to study the effect of the diuretic drug? (2 points) The selection of the ascending limb of the nephron can be attributed to the fact that the initial stage of filtration within the renal system occurs within the glomerulus. 2. What is renal perfusion and how does it affect blood pressure? (2 points) Renal perfusion plays a crucial role in the regulation and preservation of urinary output. In the scenario pertaining to hypotension. The renal output exhibits a reduction, and conversely, experiences a reciprocal effect. 3. Compare and contrast the cortical and Juxtamedullary nephrons. (2 points) Juxtamedullary nephrons exhibit a distinctive anatomical characteristic whereby their loops of Henle penetrate to greater depths within the medullary region. Cortical nephrons are characterized by possessing comparatively shorter loops of Henle. 4. What are the hormones that regulate urine output? (2 points) The antidiuretic hormone (ADH) and aldosterone hormone are two important hormones involved in the regulation of fluid balance and electrolyte levels in the body. 5. What is countercurrent multiplication in a nephron and how does it affect the urine concentration? (2 points) The phenomenon under consideration involves the use of energy in order to establish an osmotic gradient. Which facilitates enhanced water absorption and increased urine production.

BIOS256 OL, Week 4 Lab Name: Heidinette Roman 6. Reflection: Reflect on at least 2 key concepts you have learned from this simulation. How can you apply it to human health and diseases? The nephrons play a crucial role in the process of urine concentration, as they traverse from the renal cortex to the medulla of the kidneys. The kidneys perform the vital functions of filtration and excretion of superfluous solutes and poisons, while also responding directly to the concentration of urine. Grading Rubric: Activity Deliverable Points Part 1 Complete simulation 15 Part 2 Complete lab report and answer questions  Purpose (1 point)  Observation (2 points)  Questions (10 points)  Reflection (2 points) 15 Total Complete all lab activities 30

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