Lab 13 - Aspirin and Other Analgesics

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School

Georgia State University *

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Course

1152L

Subject

Chemistry

Date

Jun 8, 2024

Type

pdf

Pages

6

Uploaded by PresidentStrawAnteater30

Lab 13 - Aspirin and Other Analgesics Introduction: Aspirin is one of the most commonly used nonprescription drugs in the United States. It has multiple medical applications including reducing pain (analgesic), fever (antipyretic), and inflammation (anti-inflammatory). Aspirin is primarily composed of salicylic acid. This experiment uses synthesis experiments, vacuum filtration, pH tests, iron (III) chloride tests, and TLC chromatography to examine the properties of aspirin and other analgesics. The main goal of this experiment is successfully conduct aspirin synthesis and TLC chromatography. After completing this lab, students will be able to determine the purity of the product formed from the synthesis experiment. They will also be able interpret the results of pH tests, iron (III) chloride tests, and TLC chromatography in relation to the physical and chemical properties of aspirin. Furthermore, students will also be able to calculate theoretical yields, percent yield, Rf values, and determine the limiting agent. Finally, students will be able to identify an unknown based on the results of the multiple tests carried out during the experiment. Procedure: To begin, read the background information found on the document titled “PDF-Aspirin and Other Analgesics.” If you are completing the lab online, as done for this lab, complete the experiment by following the directions given in the online Labflow report. You will collect your data online by following those directions. If you are completing the Lab in person, please refer to the following steps. Always remember to wear appropriate PPE (safety googles, lab coat, gloves, etc.) and dispose of any chemical waste in the appropriate waste containers. Take extra caution when handling acetic anhydride as it can cause irritation. General Steps: 1) Perform the synthesis (esterification reaction) 2) Collect the aspirin product through vacuum filtration 3) Collect and analyze product data. a. Calculate the mass of salicylic acid, moles of salicylic acid, moles of acetic anhydride, theoretical yield of aspirin product, mass of aspirin synthesized, and the percent yield of the aspirin. 4) Conduct the pH test. 5) Conduct an Iron (III) Chloride test to analyze the purity of the aspirin product.
6) Conduct Thin Layer chromatography. Use aspirin, ibuprofen, acetaminophen, naproxen, caffeine, and your assigned unknown. 7) Calculate Rf values. 8) Answer all lab questions and identify the unknown. Please refer to the Labflow PDF document for detailed instructions on how to complete the lab in person. Data/Results:
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