Lab 13 - Aspirin and Other Analgesics
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Georgia State University *
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Chemistry
Date
Jun 8, 2024
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Lab 13 - Aspirin and Other Analgesics Introduction: Aspirin is one of the most commonly used nonprescription drugs in the United States. It has multiple medical applications including reducing pain (analgesic), fever (antipyretic), and inflammation (anti-inflammatory). Aspirin is primarily composed of salicylic acid. This experiment uses synthesis experiments, vacuum filtration, pH tests, iron (III) chloride tests, and TLC chromatography to examine the properties of aspirin and other analgesics. The main goal of this experiment is successfully conduct aspirin synthesis and TLC chromatography. After completing this lab, students will be able to determine the purity of the product formed from the synthesis experiment. They will also be able interpret the results of pH tests, iron (III) chloride tests, and TLC chromatography in relation to the physical and chemical properties of aspirin. Furthermore, students will also be able to calculate theoretical yields, percent yield, Rf values, and determine the limiting agent. Finally, students will be able to identify an unknown based on the results of the multiple tests carried out during the experiment. Procedure: To begin, read the background information found on the document titled “PDF-Aspirin and Other Analgesics.” If you are completing the lab online, as done for this lab, complete the experiment by following the directions given in the online Labflow report. You will collect your data online by following those directions. If you are completing the Lab in person, please refer to the following steps. Always remember to wear appropriate PPE (safety googles, lab coat, gloves, etc.) and dispose of any chemical waste in the appropriate waste containers. Take extra caution when handling acetic anhydride as it can cause irritation. General Steps: 1)
Perform the synthesis (esterification reaction) 2)
Collect the aspirin product through vacuum filtration 3)
Collect and analyze product data. a.
Calculate the mass of salicylic acid, moles of salicylic acid, moles of acetic anhydride, theoretical yield of aspirin product, mass of aspirin synthesized, and the percent yield of the aspirin. 4)
Conduct the pH test. 5)
Conduct an Iron (III) Chloride test to analyze the purity of the aspirin product.
6)
Conduct Thin Layer chromatography. Use aspirin, ibuprofen, acetaminophen, naproxen, caffeine, and your assigned unknown. 7)
Calculate Rf values. 8)
Answer all lab questions and identify the unknown. Please refer to the Labflow PDF document for detailed instructions on how to complete the lab in person. Data/Results:
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Related Questions
You have been tasked to assess a new laboratory for safety issues. The lab has a large amount of benzene, hydrochloric acid, phenol, sodium hydroxide and toluene. Describe the (5) potential hazards that can be associated with each chemical above, as well as the methods to control their potential hazards in the lab.
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In this lab you are performing your first organic synthesis and safety information on all the materials you are using must be obtained.
Companies are required to provide material safety data sheets (MSDS) for chemical compounds they sell.
Please examine the MSDS for salicylic acid, available here. You will find GHS pictograms within the sheet that summarize the main
hazards of this compound. The pictograms are essentially the same as the symbols on WHMIS labels, available here for reference.
Based on the pictograms, whatare the main hazards for salicylic acid? Select as many answers as appropriate
Select one or more:
Acute oral or inhalation toxicity
Flammable material
Carcinogen
Self-reactive substance
Gas under pressure
Corrosive
Oxidizing material
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Rxn
Reaction
AH (kl/mol) exothermic/endothermic
1 Mg0 (s) + 2 HA (aq)
2 Mg (s) + 2 Ha(aq)
з На (9) + 1/2 0, (9)
+ Mgd, (aq) + H,0 (0)
→ Mgl, (aq) + H2(g)
H20 (0)
4 Mg (s) + 1/2 o, (g)
Mg0 (s)
Accepted value for AH
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In the middle of your experiment, a corrosive chemical accidentally spilled to your laboratory gown. What should be your best course of action?
Select the correct response:
Run to the school clinic immediately and seek fırst aid from the school nurse and/or physician.
Call or text your parents about the incident and ask them for help.
Take out your lab gown and use the emergency shower to flush out the spilled chemical that have reached your clothing and skin.
Yell for help inside the laboratory room.
Go to the sink and wash your laboratory gown to remove the spilled chemical.
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Answer questions 3 and 4
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Which of the following are hazards in this lab? Choose all that apply.
Group of answer choices
NaOH
HCl
NH3
acetic acid
deionized water
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Hi, I need help with this step-by-step please thank you.
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15
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1) Which of the diet sodas have the highest concentration of caffeine? Which standard best reflects this concentration?
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Which of the following chemical tests cannot be used distinguish the twvo compounds below:
OH
vs.
Select one:
a. hot, acidic KMNO
6, Jones test
c. Lucas test
d. Tollen's test
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A1L TPN order is written for 400 mL 10% Dextrose, 300 mL 4.25% amino acids, and a total of 37 mL of additives.
How much sterile water for injection should be added?
a. 55 mL
b. 137 mL
c. 163 mL
d. 263 mL
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Draw structural formulas for organic products A and B in the window below.
H₂O
Mg
ether
●
●
●
H3CC=CH₂
Br
*8
Draw only products having the organic portion of the original alkyl halide.
Draw carbon-lithium bonds using the single bond tool. If a structure has a copper-lithium bond, do not draw the lithium.
Separate products from different steps using the → sign from the drop-down menu.
?
A
Ⓡ
ChemDoodle
B
Sn [F
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PAP Chemistry-2903012-42100P-1/ Le Chatelier's Principle/ Lesson 128
2. Zinc (Zn) granules react slowly with dilute hydrochloric acid (HCI), but much faster if the acid is concentrated.
Zn(s)
2HCI(aq)ZnCl2(aq) + H2(g)
Zinc + Hydrochloric Acid Zinc Chloride + Hydrogen
What causes the reaction to proceed faster with concentrated acid?
The concentrated hydrochloric acid causes more hydrogen gas to be produced.
The pressure of hydrogen gas molecules increases as concentration increases.
The concentrated hydrochloric acid molecules move faster than in dilute acid.
There are more collisions between the zinc and concentrated hydrochloric acid.
PREVIOU
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Please put the data in tabular format please
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What would be an appropriate shelf-life, t90, for this drug (in days) in this solution?
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Subparts 11-15
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Which of the following compounds has a different classification according to their solubility?
ac
NH₂
НО.
HS
OH
OH
OH
NH₂
F
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●
●
●
-CH₂CI
Li
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Cul
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Draw carbon-lithium bonds using the single bond tool. If a structure has a copper-lithium bond, do not draw the lithium.
Separate products from different steps using the → sign from the drop-down menu.
B
Sn [F
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Retype each equation into the adjacent box. Use the X' button for superscripts and the X, button for subscripts. Use the right
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2Na + Cl,
2NaCl
L(s) + 2e 21¯(aq)
W
étv
26
MacBook Air
DII
DD
F12
F11
F10
F9
80
F8
F7
F6
F5
F3
F4
*
&
dele
%23
$
9
く
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11:24
←
0.0
Question 5 of 13
H
Curved arrows are used to illustrate the
flow of electrons. Using the provided
starting and product structures, draw
the curved electron-pushing arrows for
the following reaction or mechanistic
steps. Be sure to account for all bond-
breaking and bond-making steps.
Select to Add Arrows
:CI:
:CI:
Select to Add
Arrows
>
I
all 35%
Submit
CI
Select to Add Arrows
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11
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Select the BEST answer to complete the statement
When a collision between reagents is ineffective,
no products are created.
only a few products are created.
bonds are broken, but not formed.
bonds are formed, but not broken.
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None
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PLEASE Answer within 20-30 minutes. Thank you!
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Eistrogens are female sex hormones, the most potent of which is B-estradiol.
OH
H,C
но
B-Estradiol
In recent years, chemists have focused on designing and synthesizing molecules that
bind to estrogen receptors. One target of this research has been nonsteroidal estrogen
antagonists, compounds that interact with estrogen receptors and block the effects of
both endogenous and exogenous estrogens. A feature common to one type of nonste-
roidal estrogen antagonist is the presence of a 1,2-diphenylethylene with one of the
benzene rings bearing a dialkylaminoethoxyl substituent. The first nonsteroidal estrogen
antagonist of this type to achieve clinical importance was tamoxifen, now an important
drug in the treatment of breast cancer. Tamoxifen has the Z configuration shown here.
но
NMe,
NMeg ?
B
NMeg ?
"NMe,
ОН
Tamoxifen
Propose reagents for the conversion of A to tamoxifen. Note: The final step in this
synthesis gives a mixture of E and Z isomers.
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7. You can see an MSDS below. Please answer the following questions related to the MSDS.
a) What is the name of this chemical?
b) What should you do if someone drinks the chemical?
c) Would this chemical catch on fire if it was exposed to flames?
d) If this chemical gets in your eye what should you do?
e) What color is this chemical?
f) What should you do if someone spills a small amount of the chemical?
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Related Questions
- You have been tasked to assess a new laboratory for safety issues. The lab has a large amount of benzene, hydrochloric acid, phenol, sodium hydroxide and toluene. Describe the (5) potential hazards that can be associated with each chemical above, as well as the methods to control their potential hazards in the lab.arrow_forwardIn this lab you are performing your first organic synthesis and safety information on all the materials you are using must be obtained. Companies are required to provide material safety data sheets (MSDS) for chemical compounds they sell. Please examine the MSDS for salicylic acid, available here. You will find GHS pictograms within the sheet that summarize the main hazards of this compound. The pictograms are essentially the same as the symbols on WHMIS labels, available here for reference. Based on the pictograms, whatare the main hazards for salicylic acid? Select as many answers as appropriate Select one or more: Acute oral or inhalation toxicity Flammable material Carcinogen Self-reactive substance Gas under pressure Corrosive Oxidizing materialarrow_forwardRxn Reaction AH (kl/mol) exothermic/endothermic 1 Mg0 (s) + 2 HA (aq) 2 Mg (s) + 2 Ha(aq) з На (9) + 1/2 0, (9) + Mgd, (aq) + H,0 (0) → Mgl, (aq) + H2(g) H20 (0) 4 Mg (s) + 1/2 o, (g) Mg0 (s) Accepted value for AHarrow_forward
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SEE MORE QUESTIONS
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Recommended textbooks for you
- Organic ChemistryChemistryISBN:9781305580350Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. FootePublisher:Cengage Learning
Organic Chemistry
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ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:Cengage Learning