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1 Principles of Genetics and Genomics Terence Doston Candy Bradbury NUR3306CBE-01CBE 5/25/23

2 Principles of Genetics and Genomics I created the following genogram to illustrate my family's health history. It includes three generations, encompassing both my parents and my paternal grandparents. My father had one brother and one sister; unfortunately his sister experienced miscarriage during gestation. On my mother's side of the family tree is stillborn sister; in turn my mother herself has been diagnosed with breast cancer. My parents are raising two children; myself and my brother. This genogram provides insight into potential patterns of disease within my family tree that may manifest themselves over time as recessive or dominant traits may manifest themselves through future generations; but other factors, including environmental exposures can also impact children's health. Healthcare professionals can use family lineages to identify genetic characteristics, determine gene inheritance patterns and predict whether certain conditions might be passed down through generations. Understanding the mode of inheritance, whether dominant, recessive, autosomal, or sex-linked, based on pedigree information is crucial. Additionally, knowledge of a patient's genomic information and family health history can help nurses identify specific risk factors and provide practical advice on preventive measures for maintaining good health. The genogram allows nurses to predict individual patients' health outcomes and provides insights into future generations. Children born with one or more defects are at an increased risk of inheriting it from their previous generation, possibly passing cancer, heart disease, or bone weakness down through generations (Crossa et al., 2017). Grandmother Grandfather Grandmother Uncle Dad Aunt Mother Aunt Me Brother Miscarriage Grandfather Still birth Breast cancer

3 In conclusion, genomics and genetic information are vital in nursing practice. Nurses can gain valuable insights into genetic patterns, potential risks, and preventive measures through genograms and comprehensive family health histories. Healthcare professionals can use this knowledge to provide tailored care and support to individuals and families, ultimately improving overall health and well-being.

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4 References Crossa, J., Pérez-Rodríguez, P., Cuevas, J., Montesinos-López, O., Jarquín, D., de los Campos, G., Burgueño, J., González-Camacho, J. M., Pérez-Elizalde, S., Beyene, Y., Dreisigacker, S., Singh, R., Zhang, X., Gowda, M., Roorkiwal, M., Rutkoski, J., & Varshney, R. K. (2017). Genomic Selection in Plant Breeding: Methods, Models, and Perspectives. Trends in Plant Science, 22(11), 961–975. https://doi.org/10.1016/j.tplants.2017.08.011 Kalia, S. S., Adelman, K., Bale, S. J., Chung, W. K., Eng, C., Evans, J. P., Herman, G. E., Hufnagel, S. B., Klein, T. E., Korf, B. R., McKelvey, K. D., Ormond, K. E., Richards, C. S., Vlangos, C. N., Watson, M., Martin, C. L., & Miller, D. T. (2016). Recommendations for reporting of secondary findings in clinical exome and genome sequencing, 2016 update (ACMG SF v2.0): a policy statement of the American College of Medical Genetics and Genomics. Genetics in Medicine, 19(2), 249–255. https://doi.org/10.1038/gim.2016.190

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