Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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Chapter 9, Problem 7CCS
Children with Muscular Disorders
You're doing a clinical rotation with Dr. Barr, a world-renowned specialist in children's muscle disorders. On your first day, you meet three patients with the same probable diagnosis—nemaline myopathy. Jodi, age 2, has a waddling walk and difficulty standing; Linda. 6 months, has pneumonia associated with problems swallowing; and Tom, 12, has progressive weakness with foot drop and difficulty walking.
“This kind of variation is not surprising.” says Dr. Barr. “A mutation in one of 11 different genes related to thin filaments can cause nemaline myopathy, so you’d expect to see it present in different ways.”
Dr. Barr has scheduled all three children for a muscle biopsy (surgical removal of a small piece of muscle tissue for examination). He explains to you. “We’re going to use these biopsies for two things. First, we're going to look for the characteristic histology of nemaline myopathy. Second, we're going to test for malignant hyperthermia. It's not associated with nemaline myopathy but is associated with a different myopathy that has a similar presentation.”
Malignant hyperthermia is caused by a mutation in a gene related to calcium storage and release in skeletal muscle cells. In individuals with malignant hyperthermia, certain anesthetics can trigger a massive release of calcium into the cytoplasm. This leads to the generation of enough heat to substantially raise body temperature—a life-threatening reaction.
7. Histology confirms nemaline myopathy in all three children. They are prescribed resistance training to strengthen their respiratory muscles. How will this affect their muscle cells?
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Chapter 9 Solutions
Human Anatomy & Physiology (11th Edition)
Ch. 9 - Prob. 1RQCh. 9 - 2. A fascicle is a (a) muscle, (b) bundle of...Ch. 9 - 3. Thick and thin myofilaments have different...Ch. 9 - 4. The function of the T tubules in muscle...Ch. 9 - 5. The sites where the motor nerve impulse is...Ch. 9 - 6. Contraction elicited by a single brief stimulus...Ch. 9 - 7. A smooth, sustained contraction resulting from...Ch. 9 - 8. Characteristics of isometric contractions...Ch. 9 - 9. During muscle contraction, ATP is provided by...Ch. 9 - 10. The neurotransmitter released by somatic motor...
Ch. 9 - 11. The ions that enter the skeletal muscle cell...Ch. 9 - 12. Myoglobin has a special function in muscle...Ch. 9 - 13. Aerobic exercise results in all of the...Ch. 9 - 14. The smooth muscle type found in the walls of...Ch. 9 - 15. Name and describe the four special functional...Ch. 9 - 16. Distinguish between (a) direct and indirect...Ch. 9 - 17. (a) Describe the structure of a sarcomere and...Ch. 9 - 18. What is the importance of acetylcholinesterase...Ch. 9 - 19. Explain how a slight (but smooth) contraction...Ch. 9 - 20. Explain what is meant by the term...Ch. 9 - 21. Define and draw a motor unit.
Ch. 9 - 23. True or false: Most muscles contain a...Ch. 9 - 24. Describe some cause(s) of muscle fatigue and...Ch. 9 - 26. Smooth muscle has some unique properties, such...Ch. 9 - 2. When a suicide victim was found, the coroner...Ch. 9 - 3. Muscle-relaxing drugs are administered to a...Ch. 9 - Children with Muscular Disorders You're doing a...Ch. 9 - Children with Muscular Disorders
You're doing a...Ch. 9 - Children with Muscular Disorders
You're doing a...Ch. 9 - Children with Muscular Disorders
You're doing a...Ch. 9 - Children with Muscular Disorders You're doing a...Ch. 9 - Children with Muscular Disorders You're doing a...Ch. 9 - Children with Muscular Disorders
You're doing a...
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