ANATOMY & PHYS VOL 2(CH 18-29) >CUSTOM<
9th Edition
ISBN: 9781307677720
Author: SALADIN
Publisher: MCG/CREATE
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Textbook Question
Chapter 9, Problem 5TYR
Which of the following terms denotes a general condition that includes the other four?
- a. gout
- b. arthritis
- c. rheumatism
- d. ostecarthritis
- e. rheumatoid arthritis
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 9 Solutions
ANATOMY & PHYS VOL 2(CH 18-29) >CUSTOM<
Ch. 9.1 - Prob. 1BYGOCh. 9.1 - Prob. 2BYGOCh. 9.1 - Prob. 3BYGOCh. 9.1 - Prob. 4BYGOCh. 9.1 - Prob. 5BYGOCh. 9.1 - Prob. 6BYGOCh. 9.1 - The fundamental definition of joint (articulation)...Ch. 9.1 - Relationships and differences between the sciences...Ch. 9.1 - Prob. 3AYLOCh. 9.1 - Prob. 4AYLO
Ch. 9.1 - Characteristics and examples of bony joints...Ch. 9.1 - Characteristics of fibrous joints (synarthroses)...Ch. 9.1 - Characteristics of cartilaginous joints...Ch. 9.2 - Prob. 7BYGOCh. 9.2 - Prob. 8BYGOCh. 9.2 - Prob. 9BYGOCh. 9.2 - Prob. 10BYGOCh. 9.2 - Prob. 11BYGOCh. 9.2 - The definition and anatomical features of a...Ch. 9.2 - General anatomy of tendons, ligaments, bursae, and...Ch. 9.2 - Three essential components of a leverCh. 9.2 - Prob. 4AYLOCh. 9.2 - Prob. 5AYLOCh. 9.2 - Variables that determine a joints range of motion...Ch. 9.2 - Prob. 7AYLOCh. 9.2 - Six kinds of synovial joints; how each is...Ch. 9.2 - The concept of zero position and how it relates to...Ch. 9.2 - Prob. 10AYLOCh. 9.2 - Prob. 11AYLOCh. 9.2 - The same for flexion, extension, hyperextension,...Ch. 9.2 - Prob. 13AYLOCh. 9.2 - Prob. 14AYLOCh. 9.3 - Prob. 12BYGOCh. 9.3 - Prob. 13BYGOCh. 9.3 - Prob. 14BYGOCh. 9.3 - Prob. 15BYGOCh. 9.3 - Prob. 16BYGOCh. 9.3 - Features of the jaw (temporomandibular) joint...Ch. 9.3 - Features of the shoulder (glenohumeral) joint...Ch. 9.3 - Prob. 3AYLOCh. 9.3 - Prob. 4AYLOCh. 9.3 - Prob. 5AYLOCh. 9.3 - Features of the ankle (talocrural) joint,...Ch. 9 - Prob. 1TYRCh. 9 - Which of the following is the least movable? a. a...Ch. 9 - Prob. 3TYRCh. 9 - Prob. 4TYRCh. 9 - Which of the following terms denotes a general...Ch. 9 - Prob. 6TYRCh. 9 - In a second-class lever, the effort a. is applied...Ch. 9 - Prob. 8TYRCh. 9 - Prob. 9TYRCh. 9 - The rotator cuff includes the tendons of all of...Ch. 9 - Prob. 11TYRCh. 9 - A fluid-filled sac that eases the movement of a...Ch. 9 - Prob. 13TYRCh. 9 - _____ is the science of movement.Ch. 9 - Prob. 15TYRCh. 9 - Prob. 16TYRCh. 9 - Prob. 17TYRCh. 9 - Prob. 18TYRCh. 9 - Prob. 19TYRCh. 9 - Prob. 20TYRCh. 9 - Prob. 1BYMVCh. 9 - Prob. 2BYMVCh. 9 - Prob. 3BYMVCh. 9 - Prob. 4BYMVCh. 9 - Prob. 5BYMVCh. 9 - Prob. 6BYMVCh. 9 - Prob. 7BYMVCh. 9 - Prob. 8BYMVCh. 9 - Prob. 9BYMVCh. 9 - Prob. 10BYMVCh. 9 - Prob. 1WWTSCh. 9 - A doctor who treats arthritis is called a...Ch. 9 - Prob. 3WWTSCh. 9 - Prob. 4WWTSCh. 9 - Prob. 5WWTSCh. 9 - Prob. 6WWTSCh. 9 - Prob. 7WWTSCh. 9 - Prob. 8WWTSCh. 9 - Synovial fluid is secreted by the bursae.Ch. 9 - Prob. 10WWTSCh. 9 - All second-class levers produce a mechanical...Ch. 9 - For each of the following joint movements, state...Ch. 9 - In order of occurrence, list the joint actions...Ch. 9 - Prob. 4TYCCh. 9 - Prob. 5TYC
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