Chapter 9, Problem 3MC

Biopharmaceutics and Pharmacokinetics:Two-Compartment Model Instant Absorption Questions SHOW ALL WORK, including equation used, variables used and each step to your solution, report your regression lines and axes names (with units if appropriate) :Calculate a-q  a) B1,   b) B2,   c) hybrid rate constant (1) d) hybrid rate constant (2) e) t1/2,dist f) t1/2,elim   g) k10 h) k12 i) k21 j) initial concentration (C0)   k) central compartment volume (V1) l) steady-state volume (Vss)   m) clearance (CL)  AUC (0→10 min) using trapezoidal rule n)  AUC (20→30 min) using trapezoidal rule o) AUCtail (AUC360→∞)   p) total AUC (using short cut method) q) volume from AUC (VAUC)

Glitazones reduce insulin resistance by binding to a transcription factor in adipocytes, thereby reducing thesecretion of fatty acids. Glitazones are taken orally (in pill form). Using pharmacokinetic modeling, deriveequations to describe how the concentration of glitazones varies in the plasma as a function of time. Yourequations should be of the form: dCglitazone /dt = something, or dMglitazone /dt = something. Your model shouldinclude three compartments: the gut, the plasma, and the fatty tissues. Make sure to include a diagram thatillustrates your thinking, state all assumptions, and define your variables. Do not solve the equations.

Case Study—Ella Review the case study and then answer Parts A through F. Ella has a family history of diabetes. She wants to follow a healthful eating pattern that can lower her risk for developing this condition. Her dietitian recommends a goal of 450 to 600 kcal per meal and advises Ella to follow the Acceptable Macronutrient Distribution Range (AMDR) for carbohydrates and the Dietary Guidelines for Americans 2015-2020, which recommend limiting added sugar. She also recommends that Ella choose whole grains rather than processed grains. Ella decides to pack a lunch to take to work every day. This morning she’s making a sandwich for her lunch.   Categories of Sandwich Options (Top of the screen) Breads Spreads Cheeses Vegetables Proteins Specific food items to select White Bread 6-inches Honey Mustard Provolone LettuceTomatoBell Peppers Turkey Part A - Reading Nutrition Facts Panels for Total Kilocalories   How many total kilocalories are in Ella’s sandwich?   _____…

, if one of the archaeological specimens lacked the celiac disease-causing epitope, how could PCR be used to identify the allele in a contemporary germplasm collection of wild wheats, and to assist in transferring the allele to modern wheat varieties?

Now you will consider the composition of lipoproteins, including where they are synthesized, how they circulate, and where the various lipid and protein components are located within the lipoprotein molecule.   Drag the appropriate labels to their respective targets.

The Oregon Wolfe Barley mapping population is unique in having 12 easily-scored morphological markers, each showing monogenic inheritance. Do you consider these markers useful? Briefly defend your answer, pointing out advantages and disadvantages of morphological vs. molecular markers.

Biopharmaceutics and Pharmacokinetics:Two-Compartment Model Instant Absorption Questions Calculate these : a) B1,   b) B2,   c) hybrid rate constant (1) d) hybrid rate constant (2) e) t1/2,dist f) t1/2,elim   g) k10 h) k12 i) k21 j) initial concentration (C0)   k) central compartment volume (V1) l) steady-state volume (Vss)   m) clearance (CL)  AUC (0→10 min) using trapezoidal rule n)  AUC (20→30 min) using trapezoidal rule o) AUCtail (AUC360→∞)   p) total AUC (using short cut method) q) volume from AUC (VAUC)

In a population of Jackalopes (pictured below), horn length will vary between 0.5 and 2 feet, with the mean length somewhere around 1.05 feet. You pick Jackalopes that have horn lengths around 1.75 feet to breed as this appears to be the optimal length for battling other Jackalopes for food. After a round of breeding, you measure the offsprings' mean horn length is 1.67. What is the heritability of horns length (h2)? Is Jackalope horn length a heritable trait? (4 pts)? 12pt v R Paragraph V BIU A श्र > B

There are many differences between DNA replication happening during mitosis in a Douglas fir tree growing in the Oregon Cascade Mountains and DNA replication happening during a PCR reaction in a forestry research lab at Oregon State University where the laboratory is amplifying a Simple Sequence Repeat. Complete the following table that compares the two DNA replication events in terms of the primers, the nucleotides, the polymerase, and the target sequence. Additionally, give a general value for the number of copies of the template DNA after one S phase in one cell and after the lab has completed the PCR reaction. Tree SSR Type your answer here: Primers Nucleotides Polymerase Target sequence Number of copies