Pearson eText Principles of Human Physiology -- Instant Access (Pearson+)
6th Edition
ISBN: 9780135213001
Author: Cindy Stanfield
Publisher: PEARSON+
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Chapter 9, Problem 11E
Summary Introduction
Introduction:
The brain is the main organ of the body and is one of the components of the central nervous system. It is divided into various parts according to their functions. It controls and regulates every function of our body.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 9 Solutions
Pearson eText Principles of Human Physiology -- Instant Access (Pearson+)
Ch. 9.1 - Describe the symptoms and causes of multiple...Ch. 9.1 - What are the main areas of commonality between...Ch. 9.1 - What are the key differences between these three...Ch. 9.1 - Prob. 1aCTQCh. 9.1 - Prob. 2aCTQCh. 9.1 - Identify differences in the treatment and expected...Ch. 9.1 - Prob. 9.1.1QCCh. 9.1 - Prob. 9.1.2QCCh. 9.1 - Prob. 9.1.3QCCh. 9.2 - Prob. 9.2.1QC
Ch. 9.2 - Prob. 9.2.2QCCh. 9.2 - Prob. 9.2.3QCCh. 9.3 - Prob. 9.3.1QCCh. 9.3 - Prob. 9.3.2QCCh. 9.3 - Prob. 9.3.3QCCh. 9.3 - For each of the following functions, indicate...Ch. 9.4 - Is salivation in response to a bell an example of...Ch. 9.4 - Prob. 9.4.2QCCh. 9.5 - Prob. 9.5.1QCCh. 9.5 - Prob. 9.5.2QCCh. 9.7 - Describe how cortisol and the autonomic nervous...Ch. 9.7 - Prob. 2CTQCh. 9.7 - What do you suppose are the limitations of current...Ch. 9.7 - Prob. 9.6.1QCCh. 9.7 -
Which types of EEG changes are observed as a...Ch. 9.7 - What is the ascending reticular activating system,...Ch. 9.9 - Prob. 9.7.1QCCh. 9.9 - Prob. 9.7.2QCCh. 9 - Prob. 1ECh. 9 - Prob. 2ECh. 9 - Prob. 3ECh. 9 - Prob. 4ECh. 9 - Prob. 5ECh. 9 -
The origin of neurons of the corticospinal tract...Ch. 9 -
Which of the following is not a component of the...Ch. 9 - Prob. 8ECh. 9 - Prob. 9ECh. 9 - Prob. 10ECh. 9 - Prob. 11ECh. 9 - Prob. 12ECh. 9 - Prob. 13ECh. 9 - Prob. 14ECh. 9 - Prob. 15ECh. 9 - Prob. 16ECh. 9 - Prob. 17ECh. 9 - Prob. 18ECh. 9 - Prob. 19ECh. 9 - Prob. 20ECh. 9 - Prob. 21ECh. 9 - Prob. 22ECh. 9 - Prob. 23ECh. 9 - Prob. 24ECh. 9 - Prob. 25ECh. 9 -
Describe the different structures that protect...Ch. 9 -
Describe the energy supply to the brain.
Ch. 9 - Prob. 28ECh. 9 - Prob. 29ECh. 9 - Prob. 30ECh. 9 -
Describe the roles of NMDA and AMPA receptors in...Ch. 9 - Prob. 32ECh. 9 -
Suppose a person suffers a stroke that affects...Ch. 9 -
Reflexes can be overridden by voluntary controls....Ch. 9 -
Paralysis refers to the inability to voluntarily...
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