ANATOMY+PHYSIOLOGY(LL)-W/CONNECT ACCESS
4th Edition
ISBN: 9781266364051
Author: McKinley
Publisher: MCG
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Chapter 8.11, Problem 36WDYL
Summary Introduction
To determine:
The reason for preference of arched foot over flat foot.
Concept introduction:
Feet are flexible bony structures that help in running, jumping, and walking. Feet are divided into parts; the forefoot consists of phalanges and metatarsals, the midfoot consists of the cuboid, navicular, and three cuneiform bones, and the hind foot consists of talus and calcaneus.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
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(e)…
Chapter 8 Solutions
ANATOMY+PHYSIOLOGY(LL)-W/CONNECT ACCESS
Ch. 8.1 - What is the general function of the axial...Ch. 8.1 - What is the difference between a foramen and a...Ch. 8.2 - Prob. 3WDYLCh. 8.2 - Prob. 4WDYLCh. 8.2 - What bones form the middle cranial fossa, and...Ch. 8.2 - Prob. 6WDYLCh. 8.2 - Prob. 7WDYLCh. 8.2 - In which four bones are the paranasal sinuses...Ch. 8.3 - Prob. 9WDYLCh. 8.4 - Prob. 10WDYL
Ch. 8.4 - What are the two largest fontanelles, and when do...Ch. 8.5 - Prob. 12WDYLCh. 8.5 - What are the secondary curves, and when do they...Ch. 8.5 - Compare the locations and functions of the...Ch. 8.5 - Prob. 15WDYLCh. 8.6 - Prob. 16WDYLCh. 8.6 - Prob. 17WDYLCh. 8.7 - Prob. 18WDYLCh. 8.8 - How do the sternal end and acromial end of the...Ch. 8.8 - Prob. 20WDYLCh. 8.9 - Prob. 21WDYLCh. 8.9 - Prob. 22WDYLCh. 8.9 - Prob. 23WDYLCh. 8.9 - Describe how the radius and ulna are positioned...Ch. 8.9 - Prob. 25WDYLCh. 8.10 - What three bones fuse to form the os coxae?Ch. 8.10 - Prob. 27WDYLCh. 8.10 - How is the pelvic inlet distinguished from the...Ch. 8.10 - Prob. 29WDYLCh. 8.10 - What are some differences in the symphysial...Ch. 8.11 - Prob. 31WDYLCh. 8.11 - Prob. 32WDYLCh. 8.11 - What are some bony features that are similar or...Ch. 8.11 - Prob. 34WDYLCh. 8.11 - Prob. 35WDYLCh. 8.11 - Prob. 36WDYLCh. 8.12 - Prob. 37WDYLCh. 8 - Prob. 1DYKBCh. 8 - Which bone marking is matched with its correct...Ch. 8 - The frontal and parietal bones articulate at the...Ch. 8 - Prob. 4DYKBCh. 8 - Prob. 5DYKBCh. 8 - Prob. 6DYKBCh. 8 - Prob. 7DYKBCh. 8 - Prob. 8DYKBCh. 8 - The femur articulates with the tibia at the a....Ch. 8 - Prob. 10DYKBCh. 8 - Prob. 11DYKBCh. 8 - Prob. 12DYKBCh. 8 - What are the functions of the paranasal sinuses?Ch. 8 - Prob. 14DYKBCh. 8 - Describe similarities and differences among true,...Ch. 8 - Compare and contrast the anatomic and functional...Ch. 8 - What are the primary similarities and differences...Ch. 8 - Prob. 18DYKBCh. 8 - Prob. 19DYKBCh. 8 - Prob. 20DYKBCh. 8 - Prob. 1CALCh. 8 - Prob. 2CALCh. 8 - Prob. 3CALCh. 8 - Prob. 4CALCh. 8 - Use the following paragraph to answer questions...Ch. 8 - Prob. 1CSLCh. 8 - Prob. 2CSLCh. 8 - Forensic anthropologists are investigating...
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